Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Efficacy of Intrauterine Lidocaine and Naproxen for Pain Control With Intrauterine Device Insertion

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2016-05-11
Last Posted Date
2018-11-08
Lead Sponsor
Walter Reed National Military Medical Center
Target Recruit Count
160
Registration Number
NCT02769247
Locations
🇺🇸

Walter Reed National Military Medical Center, Bethesda, Maryland, United States

The Effect of Perioperative Lidocaine Intravenous Infusion on Postoperative Recovery After Spine Surgery.

Phase 4
Conditions
Interventions
First Posted Date
2016-05-05
Last Posted Date
2016-05-05
Lead Sponsor
Sheba Medical Center
Target Recruit Count
60
Registration Number
NCT02762656
Locations
🇮🇱

Sheba Medical Center, Ramat Gan, Israel

Impact of 5% Lidocaine Medicated Plaster on Allodynic Symptoms of Localized Neuropathic Pain After Knee Surgery

First Posted Date
2016-05-05
Last Posted Date
2017-04-04
Lead Sponsor
University Hospital, Clermont-Ferrand
Target Recruit Count
37
Registration Number
NCT02763592
Locations
🇫🇷

CHU Clermont-Ferrand, Clermont-Ferrand, France

Perineural Dexamethasone in Femural Nerve Block After Ligament Reconstruction

First Posted Date
2016-04-22
Last Posted Date
2017-08-02
Lead Sponsor
Foisor Orthopedics Clinical Hospital
Target Recruit Count
90
Registration Number
NCT02749162
Locations
🇷🇴

Foisor Orthopedics Clinical Hospital, Bucharest, Romania

Clinical Outcomes Maxilla: Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2016-04-21
Last Posted Date
2018-12-19
Lead Sponsor
University of North Carolina, Chapel Hill
Target Recruit Count
24
Registration Number
NCT02747186
Locations
🇺🇸

University of North Carolina School of Dentistry, Chapel Hill, North Carolina, United States

Ketamine vs Propofol for Sedation During Pediatric Bronchoscopy

First Posted Date
2016-04-19
Last Posted Date
2017-04-28
Lead Sponsor
Rabin Medical Center
Target Recruit Count
150
Registration Number
NCT02743104

Multimodal Analgesia in Cardiac Surgery (Pilot Study)

First Posted Date
2016-04-12
Last Posted Date
2018-08-07
Lead Sponsor
Virginia Commonwealth University
Target Recruit Count
3
Registration Number
NCT02734940
Locations
🇺🇸

Virginia Commonwealth University, Richmond, Virginia, United States

Evaluation of the Efficacy and Safety of Administering Lidocaine Spray in Oesophago-gastro-duodenoscopy

Phase 4
Completed
Conditions
Interventions
First Posted Date
2016-04-11
Last Posted Date
2018-01-29
Lead Sponsor
Basque Health Service
Target Recruit Count
586
Registration Number
NCT02733471
Locations
🇪🇸

Araba University Hospital, Vitoria, Alava, Spain

Sphenopalatine Ganglion Block to Treat Shoulder Pain After Thoracotomy

First Posted Date
2016-04-11
Last Posted Date
2017-10-02
Lead Sponsor
NYU Langone Health
Target Recruit Count
2
Registration Number
NCT02733393
Locations
🇺🇸

New York University Langone Medical Center, New York, New York, United States

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