Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

A Study of Stellate Ganglion Block and / or Reserpine in Group 2 Pulmonary Hypertension

First Posted Date
2016-02-18
Last Posted Date
2019-05-22
Lead Sponsor
Mayo Clinic
Registration Number
NCT02684786
Locations
🇺🇸

Mayo Clinic Florida, Jacksonville, Florida, United States

The Platelet Aggregation After tiCagrelor Inhibition and FentanYl Trial (PACIFY)

First Posted Date
2016-02-17
Last Posted Date
2018-06-07
Lead Sponsor
Johns Hopkins University
Target Recruit Count
212
Registration Number
NCT02683707
Locations
🇺🇸

Johns Hopkins Hospital and University School of Medicicine, Baltimore, Maryland, United States

Sore Throat Prevention Following Intubation

First Posted Date
2016-02-15
Last Posted Date
2016-02-15
Lead Sponsor
University of Jordan
Target Recruit Count
300
Registration Number
NCT02682134

Nalbuphine as an Adjuvant to Intravenous Regional Anesthesia

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2016-02-10
Last Posted Date
2018-06-26
Lead Sponsor
Assiut University
Target Recruit Count
106
Registration Number
NCT02678585
Locations
🇪🇬

Assiut university hospital, Assiut, Egypt

The Effect of Pregabalin on Pain of Propofol Injection

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2016-01-29
Last Posted Date
2016-05-11
Lead Sponsor
Kyungpook National University Hospital
Target Recruit Count
120
Registration Number
NCT02668094
Locations
🇰🇷

Kyungpook National University Hospital, Daegu, Korea, Republic of

Continuous Adductor Canal Block With a New Catheter - Primary Placement and Secondary Repositioning

First Posted Date
2016-01-18
Last Posted Date
2017-10-19
Lead Sponsor
Kai Henrik Wiborg Lange
Target Recruit Count
16
Registration Number
NCT02657603
Locations
🇩🇰

Nordsjællands Hospital, Hillerød, Denmark

Effects of Perioperative Intravenous Lidocaine and Ketamine on Acute and Chronic Pain After Open Nephrectomy

First Posted Date
2016-01-12
Last Posted Date
2016-07-28
Lead Sponsor
University Tunis El Manar
Target Recruit Count
60
Registration Number
NCT02653651
Locations
🇹🇳

Ali JENDOUBI, Tunis, Tunisia

Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2016-01-06
Last Posted Date
2023-08-21
Lead Sponsor
University of Nebraska
Target Recruit Count
70
Registration Number
NCT02647892
Locations
🇺🇸

University of Nebraska Medical Center, Omaha, Nebraska, United States

Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica)

First Posted Date
2015-12-31
Last Posted Date
2018-03-19
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
18
Registration Number
NCT02644421
Locations
🇺🇸

Translational Pain Research, Brigham and Women's Hospital, Boston, Massachusetts, United States

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