Lidocaine

Generic Name: Lidocaine

Brand Names: Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₂₂N_₂O

CAS Number: 137-58-6

Unique Ingredient Identifier: 98PI200987

Background: Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication: Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions: Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal

Associated Therapies: Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Clinical Trials

Intravenous Lidocaine for Post-Tonsillectomy Pain in Pediatric Patients

Phase 2

Completed

Conditions: Pain

Interventions: Drug: Saline
Drug: Lidocaine

First Posted Date: 2015-11-03

Last Posted Date: 2024-11-12

Lead Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Target Recruit Count: 89

Registration Number: NCT02595463

Locations: 🇺🇸
Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois, United States

The Efficacy of Local Anesthetics to Reduce Shoulder Pain Post-Steroid Injections

Phase 4

Terminated

Conditions: Shoulder Pain

Interventions: Drug: lidocaine
Drug: Kenalog
Drug: ethyl chloride

First Posted Date: 2015-10-30

Last Posted Date: 2018-10-16

Lead Sponsor: Milton S. Hershey Medical Center

Target Recruit Count: 19

Registration Number: NCT02592629

Locations: 🇺🇸
Penn State College of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States

Anesthesia Lumbar Puncture In Children

Not Applicable

Conditions: Spinal Puncture
Anesthesia

Interventions: Drug: Lidocaine

First Posted Date: 2015-10-29

Last Posted Date: 2015-10-29

Lead Sponsor: Beijing Children's Hospital

Target Recruit Count: 200

Registration Number: NCT02590705

Engage 24: Evaluation of the Safety and Effectiveness of URG101 in Subjects With Interstitial Cystitis/Bladder Pain Syndrome

Phase 2

Terminated

Conditions: Bladder Pain Syndrome
Interstitial Cystitis

Interventions: Drug: Lidocaine
Drug: URG101
Drug: Placebo
Drug: Heparin

First Posted Date: 2015-10-29

Last Posted Date: 2020-08-26

Lead Sponsor: Urigen

Target Recruit Count: 92

Registration Number: NCT02591199

Locations: 🇺🇸
IC Study, LLC, Escondido, California, United States
🇺🇸
Rutgers Women's Health Clinic, New Brunswick, New Jersey, United States
🇺🇸
University of California San Diego, San Diego, California, United States

and more 8 locations