Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

General Anesthesia for Endovascular Thrombectomy; A Pilot Study.

First Posted Date
2015-12-24
Last Posted Date
2023-12-08
Lead Sponsor
University of Saskatchewan
Target Recruit Count
34
Registration Number
NCT02639806
Locations
🇨🇦

Royal University Hospital, Saskatoon, Saskatchewan, Canada

Intra-Articular 0.5 % Lidocaine Injection for Osteoarthritis

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-12-16
Last Posted Date
2015-12-16
Lead Sponsor
H. Evren Eker
Target Recruit Count
52
Registration Number
NCT02632565

Perioperative Intravenous Lidocaine Infusion for Patients Undergoing Laparoscopic and Open Pancreatectomies

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-12-08
Last Posted Date
2019-04-16
Lead Sponsor
Mayo Clinic
Target Recruit Count
48
Registration Number
NCT02623803
Locations
🇺🇸

Mayo Clinic Florida, Jacksonville, Florida, United States

Does Use of Topical Lidocaine in EGD Reduce Amount of IV Midazolam and Fentanyl Required and Shorten Recovery Time

Not Applicable
Conditions
Interventions
First Posted Date
2015-12-03
Last Posted Date
2015-12-03
Lead Sponsor
Brooke Army Medical Center
Target Recruit Count
106
Registration Number
NCT02620501
Locations
🇺🇸

Brooke Army Medical Center, Ft. Sam Houston, Texas, United States

Clinical Outcomes of Buffered vs. Non-Buffered Lidocaine

First Posted Date
2015-12-03
Last Posted Date
2018-01-23
Lead Sponsor
University of North Carolina, Chapel Hill
Target Recruit Count
23
Registration Number
NCT02620683
Locations
🇺🇸

UNC School of Dentistry, Chapel Hill, North Carolina, United States

Influence of Dexmedetomidine and Lidocaine on Opioid Consumption in Laparoscopic Intestine Resection

First Posted Date
2015-11-30
Last Posted Date
2016-10-11
Lead Sponsor
University Medical Centre Ljubljana
Target Recruit Count
60
Registration Number
NCT02616523

Effect of Perioperative Intravenous Lidocaine on Opioid Consumption and Pain After Laparoscopic Totally Extraperitoneal Inguinal Hernioplasty

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-11-10
Last Posted Date
2018-09-25
Lead Sponsor
B.P. Koirala Institute of Health Sciences
Target Recruit Count
64
Registration Number
NCT02601651
Locations
🇳🇵

BP Koirala institute of health sciences, Dharan, Sunsari, Nepal

Efficacy and Safety of Lidocaine Infusion Treatment in Management of Neuropathic Pain

First Posted Date
2015-11-05
Last Posted Date
2015-11-05
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
44
Registration Number
NCT02597257
Locations
🇰🇷

Yong Chul Kim, Seoul, Korea, Republic of

Pilot Study of Effect of Intravenous Lidocaine on Propofol Requirement in Facial Plastic Surgery

First Posted Date
2015-11-05
Last Posted Date
2019-07-30
Lead Sponsor
Chung-Ang University Hosptial, Chung-Ang University College of Medicine
Target Recruit Count
40
Registration Number
NCT02597140
Locations
🇰🇷

Chung-Ang University Hospital, Seoul, Korea, Republic of

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