Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

A Trial of Local Anaesthesia Versus Local Anaesthesia and Conscious Sedation for Hernioplasty

First Posted Date
2015-05-14
Last Posted Date
2015-05-14
Lead Sponsor
The University of The West Indies
Target Recruit Count
180
Registration Number
NCT02444260
Locations
🇯🇲

University of the West Indies, mona, Kingston, Please Select, Jamaica

Pain With Trigger Finger Injection: A Comparison of Steroid Alone Versus Steroid/Lidocaine Mixture

First Posted Date
2015-04-20
Last Posted Date
2018-09-28
Lead Sponsor
Kenneth Taylor, M.D.
Target Recruit Count
26
Registration Number
NCT02421419
Locations
🇺🇸

Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States

Anesthetics in Rhytidoplasty - A Comparison Study

First Posted Date
2015-04-07
Last Posted Date
2015-04-07
Lead Sponsor
Mercy Facial Plastic Surgery Center
Target Recruit Count
30
Registration Number
NCT02410460
Locations
🇺🇸

Mercy Facial Plastic Surgery Center, Springfield, Missouri, United States

Efficacy of Topical Lidocaine to Decrease Discomfort With Intranasal Midazolam Administration

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2015-03-24
Last Posted Date
2017-02-23
Lead Sponsor
University of Alabama at Birmingham
Target Recruit Count
77
Registration Number
NCT02396537

Clinical Assessment of the Treatment With Cardiac Sympathetic Blockade on Chronic Heart Failure

Not Applicable
Conditions
Interventions
First Posted Date
2015-03-18
Last Posted Date
2018-08-08
Lead Sponsor
First Affiliated Hospital of Harbin Medical University
Target Recruit Count
100
Registration Number
NCT02391142
Locations
🇨🇳

the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China

Paraspinal Block in Nonspecific Low Back Pain

First Posted Date
2015-03-13
Last Posted Date
2015-03-13
Lead Sponsor
Marta Imamura
Target Recruit Count
378
Registration Number
NCT02387567
Locations
🇧🇷

Hospital das Clinicas, Sao Paulo, Brazil

Lidocaine for Diabetic Peripheral Neuropathy

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2015-02-16
Last Posted Date
2019-11-15
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
34
Registration Number
NCT02363803
Locations
🇺🇸

Washington University School of Medicine/Barnes Jewish Hospital, Saint Louis, Missouri, United States

Endovenous Lidocaine and Serum Cytokines Concentration

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-02-16
Last Posted Date
2015-02-16
Lead Sponsor
Universidade Federal de Santa Maria
Target Recruit Count
44
Registration Number
NCT02363699

The Effects of Lidocaine and Magnesium Sulphate on the Attenuation of the Hemodynamic Response to Tracheal Intubation

First Posted Date
2015-02-10
Last Posted Date
2015-02-10
Lead Sponsor
Hospital de Base
Target Recruit Count
49
Registration Number
NCT02359370

Intranasal Midazolam in Children as a Pre-Operative Sedative - Part 2

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-02-05
Last Posted Date
2022-03-16
Lead Sponsor
Jennifer Victory, RN, CCRC
Target Recruit Count
42
Registration Number
NCT02356705
Locations
🇺🇸

Bassett Healthcare Network, Cooperstown, New York, United States

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