Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

The Effect of Local Anesthetic Volume Within the Adductor Canal on Quadriceps Function Evaluated by Electromyography

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-01-26
Last Posted Date
2015-01-29
Lead Sponsor
Ulrik Grevstad
Target Recruit Count
20
Registration Number
NCT02344589
Locations
🇩🇰

Rigshospitalet, Copenhagen, Denmark

Ultrasound-guided Sacroiliac Joint Radiofrequency Ablation: A Pilot Study

First Posted Date
2015-01-09
Last Posted Date
2019-05-01
Lead Sponsor
Western University, Canada
Target Recruit Count
31
Registration Number
NCT02335190
Locations
🇨🇦

St. Joseph's Pain Clinic, London, Ontario, Canada

Cefazolin-Lidocaine Combination Solution to Reduce Antibiotic Pain

First Posted Date
2014-12-24
Last Posted Date
2014-12-24
Lead Sponsor
University Health Network, Toronto
Target Recruit Count
54
Registration Number
NCT02324166

Intranasal Midazolam in Children as a Pre-Operative Sedative

First Posted Date
2014-12-11
Last Posted Date
2015-07-23
Lead Sponsor
Bassett Healthcare
Target Recruit Count
15
Registration Number
NCT02314546
Locations
🇺🇸

Bassett Healthcare Network, Cooperstown, New York, United States

Effect of Intravenous Infusion of Lidocaine and Remifentanil Perioperatively in Patients Undergoing Mastectomy

Phase 4
Completed
Conditions
Interventions
First Posted Date
2014-11-14
Last Posted Date
2014-11-25
Lead Sponsor
Hospital de Base
Target Recruit Count
60
Registration Number
NCT02291094

Epidural Anesthesia With Chloroprocaine Versus Lidocaine

Phase 4
Completed
Conditions
Interventions
First Posted Date
2014-11-11
Last Posted Date
2014-11-11
Lead Sponsor
Jinling Hospital, China
Target Recruit Count
120
Registration Number
NCT02287870

Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine

First Posted Date
2014-10-27
Last Posted Date
2015-06-25
Lead Sponsor
Ain Shams Maternity Hospital
Target Recruit Count
160
Registration Number
NCT02274974
Locations
🇪🇬

Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine;, Cairo, Egypt

Does Intraperitoneal Instillation of Lidocaine at Cesarean Delivery Improve Postoperative Analgesia?

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2014-10-15
Last Posted Date
2016-05-03
Lead Sponsor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Target Recruit Count
204
Registration Number
NCT02264795
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

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