Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Intravenous Lidocaine and Quality of Recovery After Cesarean Delivery

Not Applicable
Withdrawn
Conditions
Interventions
First Posted Date
2014-10-06
Last Posted Date
2022-06-09
Lead Sponsor
Northwestern University
Registration Number
NCT02257346
Locations
🇺🇸

NorthwesternUniversity, Chicago, Illinois, United States

Preoperative Intraarticular Injection of Methylprednisolone in Patients Scheduled for Total Knee-arthroplasty

First Posted Date
2014-10-01
Last Posted Date
2016-06-06
Lead Sponsor
Rigshospitalet, Denmark
Target Recruit Count
48
Registration Number
NCT02253966
Locations
🇩🇰

Gentofte Hospital, Hellerup, Denmark

Ultrasound-guided Pulsed Radiofrequency for Plantar Fasciitis

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2014-09-17
Last Posted Date
2016-12-01
Lead Sponsor
Yung-Tsan Wu
Target Recruit Count
36
Registration Number
NCT02242513
Locations
🇨🇳

Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Neihu District, Taiwan

PK Intravenous Lidocaine Infusion

Phase 1
Terminated
Conditions
Interventions
First Posted Date
2014-09-16
Last Posted Date
2020-03-02
Lead Sponsor
Children's Hospital Medical Center, Cincinnati
Target Recruit Count
2
Registration Number
NCT02241096
Locations
🇺🇸

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

Re-administration of Intramuscular AAV9 in Patients With Late-Onset Pompe Disease

First Posted Date
2014-09-15
Last Posted Date
2022-04-05
Lead Sponsor
University of Florida
Target Recruit Count
2
Registration Number
NCT02240407
Locations
🇺🇸

Clinical and Translational Research Building (CTRB), University of Florida, Gainesville, Florida, United States

Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection

First Posted Date
2014-09-15
Last Posted Date
2016-06-22
Lead Sponsor
The University of Texas Health Science Center, Houston
Target Recruit Count
76
Registration Number
NCT02240628
Locations
🇺🇸

Memorial Hermann Hospital, Houston, Texas, United States

Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury.

Phase 4
Completed
Conditions
Interventions
First Posted Date
2014-09-01
Last Posted Date
2024-07-01
Lead Sponsor
University of Florida
Target Recruit Count
34
Registration Number
NCT02229578
Locations
🇺🇸

Shands Hospital, Gainesville, Florida, United States

🇺🇸

Shands Hospital, University of Florida, Gainesville, Florida, United States

Surgery Prevention by Transforaminal Injection of Epidural Steroids for Cervical Radicular Pain

First Posted Date
2014-08-27
Last Posted Date
2024-04-23
Lead Sponsor
OrthoCarolina Research Institute, Inc.
Target Recruit Count
65
Registration Number
NCT02226159
Locations
🇺🇸

OrthoCarolina, Charlotte, North Carolina, United States

Comparison of Effect on Quality of Recovery Outcome Between Systemic Lidocaine and Dexamethasone in Patients Undergoing Laparoscopic Cholecystectomy

First Posted Date
2014-08-25
Last Posted Date
2019-03-19
Lead Sponsor
Yonsei University
Target Recruit Count
8
Registration Number
NCT02224170
Locations
🇰🇷

Department of Surgery, Yonsei University College of Medicine, Seoul, Korea, Seoul, Korea, Republic of

Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial

First Posted Date
2014-08-18
Last Posted Date
2018-03-22
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
26
Registration Number
NCT02218203
Locations
🇺🇸

Translational Pain Research, Brigham and Women's Hospital, Boston, Massachusetts, United States

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