Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation

First Posted Date
2014-03-26
Last Posted Date
2020-05-27
Lead Sponsor
Sheba Medical Center
Target Recruit Count
134
Registration Number
NCT02097017
Locations
🇮🇱

Sheba Medical Center, Ramat Gan, Israel

Navigator vs Standard Needle Injection for Hip

Phase 2
Completed
Conditions
Interventions
First Posted Date
2014-02-20
Last Posted Date
2016-01-28
Lead Sponsor
Cartiva, Inc.
Target Recruit Count
40
Registration Number
NCT02066844
Locations
🇺🇸

University of Rochester, Rochester, New York, United States

Continuous Lidocaine Infusion for Management of Perioperative Burn Pain

Phase 4
Completed
Conditions
Interventions
First Posted Date
2014-02-11
Last Posted Date
2018-07-03
Lead Sponsor
HealthPartners Institute
Target Recruit Count
36
Registration Number
NCT02059902
Locations
🇺🇸

Regions Hospital, Saint Paul, Minnesota, United States

ED95 of Lidocaine 1.0% for Filling the Adductor Canal

First Posted Date
2014-01-10
Last Posted Date
2014-04-04
Lead Sponsor
Rigshospitalet, Denmark
Target Recruit Count
40
Registration Number
NCT02033356
Locations
🇩🇰

Aleris-Hamlet Hospitals Copenhagen, Søborg, Denmark

Routine Irrigation With Ropivacaine vs. Lidocaine vs. Saline of Surgical Bed in Sleeve Gastrectomy

First Posted Date
2013-12-30
Last Posted Date
2013-12-30
Lead Sponsor
The Baruch Padeh Medical Center, Poriya
Target Recruit Count
90
Registration Number
NCT02023684
Locations
🇮🇱

General Surgery Ward, Poriya, The Lower Galilee, Israel

Effect of Perioperative Intravenous Lidocaine Infusion and Magnesium Infusion on the Functional Recovery After General Anesthesia in the Patients Undergoing Thyroid Surgery

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2013-12-23
Last Posted Date
2015-02-02
Lead Sponsor
Yonsei University
Target Recruit Count
135
Registration Number
NCT02018276
Locations
🇰🇷

Department of Anesthesiology and Pain MedicineSeverance Hospital, Yonsei University Health System, Seoul, Korea, Republic of

Safety and Efficacy Study of Lidocaine Mixed Hyaluronate on Nasolabial Folds Correction

Not Applicable
Withdrawn
Conditions
Interventions
First Posted Date
2013-12-10
Last Posted Date
2016-04-29
Lead Sponsor
SciVision Biotech Inc.
Registration Number
NCT02006173
Locations
🇨🇳

Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan

Provoked, Localized Vulvodynia Treatment With Acupuncture and Lidocaine Pilot Study

First Posted Date
2013-11-27
Last Posted Date
2017-10-06
Lead Sponsor
Oregon College of Oriental Medicine
Target Recruit Count
19
Registration Number
NCT01996384
Locations
🇺🇸

Women's Health Research Unit; Oregon Health & Science University, Portland, Oregon, United States

The Simultaneous Use of Supraclavicular and Distal Blocks

First Posted Date
2013-11-21
Last Posted Date
2013-11-21
Lead Sponsor
Ankara University
Target Recruit Count
75
Registration Number
NCT01989312
Locations
🇹🇷

Ankara University Faculty of Medicine, Ibni Sina Hospital colonoscopy lab, Ankara, Turkey

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