Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Effect of Esmolol on Pain Due to Rocuronium

First Posted Date
2013-04-05
Last Posted Date
2019-10-04
Lead Sponsor
Ankara Diskapi Training and Research Hospital
Target Recruit Count
90
Registration Number
NCT01824758
Locations
🇹🇷

Diskapi Teaching and Research Hospital, Ankara, Altindag, Turkey

Intrathecal Magnesium for Same-day-surgery

First Posted Date
2013-02-18
Last Posted Date
2014-03-10
Lead Sponsor
Hospital General de Ciudad Real
Target Recruit Count
21
Registration Number
NCT01794247
Locations
🇪🇸

Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

🇪🇸

Hospital General universitario de Ciudad Real, Ciudad Real, Castilla-La Mancha, Spain

Lidocaine Analgesia for Urethral Catheterization in Children

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2013-01-31
Last Posted Date
2016-04-11
Lead Sponsor
Seattle Children's Hospital
Target Recruit Count
80
Registration Number
NCT01780324
Locations
🇺🇸

Seattle Children's Hospital, Seattle, Washington, United States

Pain on Injection of Propofol: a Comparison of Lidocaine and Alkalinized Lidocaine

First Posted Date
2013-01-23
Last Posted Date
2013-01-23
Lead Sponsor
Inonu University
Target Recruit Count
300
Registration Number
NCT01773044
Locations
🇹🇷

Inonu university medicine faculty, Malatya, Turkey

Local Anesthetics for Pain Reduction Prior to IV Line Placement

First Posted Date
2013-01-03
Last Posted Date
2022-07-15
Lead Sponsor
Allina Health System
Target Recruit Count
150
Registration Number
NCT01759459
Locations
🇺🇸

United Hospital, part of Allina Health Services, Saint Paul, Minnesota, United States

Bupivacaine Versus Lidocaine Local Anesthesia

First Posted Date
2012-12-18
Last Posted Date
2015-12-14
Lead Sponsor
University of British Columbia
Target Recruit Count
135
Registration Number
NCT01751347
Locations
🇨🇦

Vancouver General Hospital, Vancouver, British Columbia, Canada

The Effect of Topical Lidocaine on Pain Scores During Manual Vacuum Aspiration for Nonviable Pregnancies

Phase 3
Completed
Conditions
Interventions
First Posted Date
2012-10-16
Last Posted Date
2016-07-20
Lead Sponsor
Bridgeport Hospital
Target Recruit Count
70
Registration Number
NCT01708330
Locations
🇺🇸

Women and Infants Hospital Triage, Providence, Rhode Island, United States

Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies.

First Posted Date
2012-09-26
Last Posted Date
2020-02-05
Lead Sponsor
University Hospital, Montpellier
Target Recruit Count
50
Registration Number
NCT01694134
Locations
🇫🇷

Hospital University of Montpellier, Montpellier, France

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