Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .
Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .
Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .
Northwestern University, Chicago, Illinois, United States
Hopital Foch, Suresnes, Ile de France, France
The Hospital for Sick Children, Toronto, Ontario, Canada
Outpatient Clinic, Toronto, Ontario, Canada
Ain shams university hospital, Cairo, Egypt
GSK Investigational Site, Manchester, United Kingdom
Hospital Universitario Infanta Cristina, Parla, Madrid, Spain
Ajou University School of Medicine, Suwon, Korea, Republic of
University of Montreal, Montreal, Quebec, Canada
Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada
Centre for Applied Urological Research/Kingston General Hospital, Kingston, Ontario, Canada
College of Medicine - King Saud University Medical City, Riyadh, Saudi Arabia
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