Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Brain Imaging of Lidoderm for Chronic Back Pain

Phase 4
Completed
Conditions
Interventions
First Posted Date
2012-01-24
Last Posted Date
2013-07-30
Lead Sponsor
Northwestern University
Target Recruit Count
38
Registration Number
NCT01515540
Locations
🇺🇸

Northwestern University, Chicago, Illinois, United States

Effect of Epidural Analgesia on the Parameter ANI During Childbirth

Not Applicable
Terminated
Conditions
Interventions
First Posted Date
2012-01-06
Last Posted Date
2016-11-03
Lead Sponsor
Hopital Foch
Target Recruit Count
42
Registration Number
NCT01505283
Locations
🇫🇷

Hopital Foch, Suresnes, Ile de France, France

Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain

First Posted Date
2012-01-02
Last Posted Date
2015-11-10
Lead Sponsor
The Hospital for Sick Children
Target Recruit Count
352
Registration Number
NCT01503060
Locations
🇨🇦

The Hospital for Sick Children, Toronto, Ontario, Canada

🇨🇦

Outpatient Clinic, Toronto, Ontario, Canada

Efficacy Study of Topical Application of Lidacaine Spray Prior to IUD Insertion

Phase 4
Conditions
Interventions
First Posted Date
2011-12-21
Last Posted Date
2011-12-21
Lead Sponsor
Ain Shams University
Target Recruit Count
200
Registration Number
NCT01496105
Locations
🇪🇬

Ain shams university hospital, Cairo, Egypt

The Safety, Tolerability, PK and PD of GSK2339345 in Healthy Subjects

First Posted Date
2011-12-19
Last Posted Date
2017-06-20
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
31
Registration Number
NCT01494636
Locations
🇬🇧

GSK Investigational Site, Manchester, United Kingdom

Usefulness of Lidocaine as Topical Pharyngeal Anaesthesia in Esophagogastroduodenoscopy Under Sedation With Propofol

Phase 4
Completed
Conditions
Interventions
First Posted Date
2011-12-12
Last Posted Date
2013-03-08
Lead Sponsor
Hospital Universitario Infanta Cristina
Target Recruit Count
120
Registration Number
NCT01489891
Locations
🇪🇸

Hospital Universitario Infanta Cristina, Parla, Madrid, Spain

Intubating Conditions During Propofol-remifentanil Anesthesia With Topical Lidocaine

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2011-12-12
Last Posted Date
2012-07-16
Lead Sponsor
Ajou University School of Medicine
Target Recruit Count
50
Registration Number
NCT01489683
Locations
🇰🇷

Ajou University School of Medicine, Suwon, Korea, Republic of

Efficacy of a Physiotherapy Treatment in Women Suffering From Provoked Vestibulodynia

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2011-10-19
Last Posted Date
2016-11-04
Lead Sponsor
Université de Sherbrooke
Target Recruit Count
212
Registration Number
NCT01455350
Locations
🇨🇦

University of Montreal, Montreal, Quebec, Canada

🇨🇦

Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada

Intraureteral Lidocaine for Post-Ureteroscopy Pain

First Posted Date
2011-10-12
Last Posted Date
2013-11-06
Lead Sponsor
Queen's University
Target Recruit Count
48
Registration Number
NCT01450566
Locations
🇨🇦

Centre for Applied Urological Research/Kingston General Hospital, Kingston, Ontario, Canada

The Effect of Intravenous Lidocaine on Post-extubation Laryngospasm

Not Applicable
Terminated
Conditions
Interventions
First Posted Date
2011-10-04
Last Posted Date
2017-05-22
Lead Sponsor
King Saud University
Target Recruit Count
134
Registration Number
NCT01445847
Locations
🇸🇦

College of Medicine - King Saud University Medical City, Riyadh, Saudi Arabia

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