Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Intravitreal Injections of Sirolimus in the Treatment of Geographic Atrophy

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2012-08-30
Last Posted Date
2015-12-10
Lead Sponsor
National Eye Institute (NEI)
Target Recruit Count
52
Registration Number
NCT01675947
Locations
🇺🇸

University of Florida HSC, Jacksonville, Florida, United States

🇺🇸

Vision Research Foundation, Grand Rapids, Michigan, United States

🇺🇸

Elman Retina Group, Baltimore, Maryland, United States

and more 10 locations

Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2012-08-27
Last Posted Date
2020-03-19
Lead Sponsor
Albert Einstein Healthcare Network
Target Recruit Count
21
Registration Number
NCT01673061
Locations
🇺🇸

Albert Einstein Medical Center, Philadelphia, Pennsylvania, United States

The Role of Intravenous (IV) Lidocaine in the Management of Chronic Neuropathic Pain of Peripheral Nerve Origin

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2012-08-21
Last Posted Date
2019-03-15
Lead Sponsor
Lawson Health Research Institute
Target Recruit Count
34
Registration Number
NCT01669967
Locations
🇨🇦

St. Joseph's Health Care, London, Ontario, Canada

The Effect of Virtual Reality Glasses on Pain and Anxiety

First Posted Date
2012-08-07
Last Posted Date
2012-08-08
Lead Sponsor
Mashhad University of Medical Sciences
Target Recruit Count
30
Registration Number
NCT01659359

Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children

Not Applicable
Terminated
Conditions
Interventions
First Posted Date
2012-06-27
Last Posted Date
2019-06-21
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
66
Registration Number
NCT01628874
Locations
🇺🇸

Children's Hospital Colorado, Aurora, Colorado, United States

Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients

Phase 4
Completed
Conditions
Interventions
First Posted Date
2012-06-19
Last Posted Date
2014-03-17
Lead Sponsor
University of California, San Francisco
Target Recruit Count
20
Registration Number
NCT01622296
Locations
🇺🇸

University of California, San Francisco, San Francisco, California, United States

A Randomized, Double-blind, Placebo- and Active-controlled Study of the Electric Current Effects of ABT-639 on the Spontaneous Activity of Pain Sensory Receptors in Patients With Diabetic Peripheral Neuropathy

First Posted Date
2012-05-02
Last Posted Date
2013-01-03
Lead Sponsor
AbbVie (prior sponsor, Abbott)
Target Recruit Count
39
Registration Number
NCT01589432
Locations
🇬🇧

Site Reference ID/Investigator# 68882, London, United Kingdom

Intrauterine Lidocaine for Laminaria

First Posted Date
2012-02-29
Last Posted Date
2014-05-14
Lead Sponsor
University of North Carolina, Chapel Hill
Target Recruit Count
72
Registration Number
NCT01541293
Locations
🇺🇸

University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States

Self-administered Intravaginal 2% Lidocaine Gel Prior to Intrauterine Device Insertion in Nulliparous Women

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2012-02-16
Last Posted Date
2016-12-22
Lead Sponsor
University of Pittsburgh
Target Recruit Count
61
Registration Number
NCT01534520
Locations
🇺🇸

Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States

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