Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Intravenous Lidocaine in the Prevention of Postoperative Vomiting in Elective Tonsil Surgery

First Posted Date
2013-11-18
Last Posted Date
2015-09-24
Lead Sponsor
Pontificia Universidad Catolica de Chile
Target Recruit Count
92
Registration Number
NCT01986309
Locations
🇨🇱

División de Anestesia - Facultad de Medicina Pontificia Universidad Católica, Santiago, Región Metropolitana, Chile

Peri-Operative Lidocane, Ketamine, or Lidocane and Ketamine Combination, Infusion for Patients Undergoing Spine Surgery

First Posted Date
2013-11-13
Last Posted Date
2017-05-15
Lead Sponsor
Beth Israel Medical Center
Target Recruit Count
46
Registration Number
NCT01983020
Locations
🇺🇸

Beth Israel Medical Center, New York, New York, United States

Determination of the Effective Volume of 0.125% Bupivacaine-fentanyl 5mcg/mL in Labour Epidurals

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2013-10-30
Last Posted Date
2014-06-04
Lead Sponsor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Target Recruit Count
80
Registration Number
NCT01972269
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

Study of Local Anesthesia as a Method to Decrease IUD Insertion Related Pain

First Posted Date
2013-10-22
Last Posted Date
2017-06-12
Lead Sponsor
Johns Hopkins University
Registration Number
NCT01967017
Locations
🇺🇸

Johns Hopkins Bayview Medical Center, Baltimore, Maryland, United States

Comparison of Preincisional Infiltrated Dexmedetomidine and Lidocaine Plus Adrenaline for Nasal Sephoplasty Surgery.

First Posted Date
2013-10-17
Last Posted Date
2013-10-17
Lead Sponsor
TC Erciyes University
Target Recruit Count
60
Registration Number
NCT01964586

The Effect of Intravenous Lidocaine on Trigeminal Neuralgia

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2013-10-08
Last Posted Date
2013-10-08
Lead Sponsor
Pain Relief & Palliative Care Center, Athens, Greece
Target Recruit Count
20
Registration Number
NCT01955967

Intraoperative Lidocaine Infusion for Postoperative Pain Management in Obese Patients

Phase 3
Completed
Conditions
Interventions
First Posted Date
2013-09-17
Last Posted Date
2017-10-26
Lead Sponsor
University of South Florida
Target Recruit Count
20
Registration Number
NCT01944098
Locations
🇺🇸

Tampa General Hospital, Tampa, Florida, United States

Effect of Perioperative Intravenous Lidocaine on Postoperative Quality of Recovery in Patients Undergoing Spine Surgery

Phase 2
Withdrawn
Conditions
Interventions
First Posted Date
2013-08-29
Last Posted Date
2015-10-01
Lead Sponsor
Baylor College of Medicine
Registration Number
NCT01930877
Locations
🇺🇸

Ben Taub General Hospital, Houston, Texas, United States

Intravenous Lidocaine Infusion in the Management of Post-operative Pain in Colorectal Patients

Phase 1
Withdrawn
Conditions
Interventions
First Posted Date
2013-04-22
Last Posted Date
2016-03-08
Lead Sponsor
Children's Hospital Medical Center, Cincinnati
Registration Number
NCT01836614
Locations
🇺🇸

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

Evaluation of Oral Midazolam in First-trimester Surgical Abortions

First Posted Date
2013-04-12
Last Posted Date
2018-06-25
Lead Sponsor
Oregon Health and Science University
Target Recruit Count
124
Registration Number
NCT01830881
Locations
🇺🇸

Planned Parenthood Columbia Willamette, Portland, Oregon, United States

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