Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Topical Lidocaine for Pain Control With Intrauterine Device (IUD) Insertion

Early Phase 1
Completed
Conditions
Interventions
First Posted Date
2011-10-04
Last Posted Date
2014-08-26
Lead Sponsor
University of Wisconsin, Madison
Target Recruit Count
40
Registration Number
NCT01445756
Locations
🇺🇸

University Health Services Women's Care Clinic, Madison, Wisconsin, United States

Lidocaine Subcutaneous Infusion for Control of Treprostinil Related Site Pain

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2011-09-13
Last Posted Date
2023-02-01
Lead Sponsor
Jewish General Hospital
Target Recruit Count
4
Registration Number
NCT01433328
Locations
🇨🇦

Jewish General Hospital, Montreal, Quebec, Canada

Liposomal Lidocaine Gel for Oral Topical Anesthesia

Phase 1
Completed
Conditions
Interventions
First Posted Date
2011-08-30
Last Posted Date
2011-08-30
Lead Sponsor
University of Campinas, Brazil
Target Recruit Count
40
Registration Number
NCT01425840
Locations
🇧🇷

Piracicaba Dental School, Piracicaba, São Paulo, Brazil

Adjunctive Local Application of Lidocaine During Scleral Buckling Under General Anesthesia

Phase 4
Conditions
Interventions
First Posted Date
2011-08-16
Last Posted Date
2011-08-16
Lead Sponsor
Isfahan University of Medical Sciences
Target Recruit Count
30
Registration Number
NCT01417572
Locations
🇮🇷

Isfahan University of Medical Sciences, Isfahan, Iran, Islamic Republic of

Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch

First Posted Date
2011-08-12
Last Posted Date
2018-04-23
Lead Sponsor
Astellas Pharma Inc
Target Recruit Count
122
Registration Number
NCT01416116
Locations
🇧🇪

Site 102, Antwerpen, Belgium

🇧🇪

Site 103, Genk, Belgium

🇧🇪

Site 101, Roeselare, Belgium

and more 17 locations

Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia

First Posted Date
2011-07-25
Last Posted Date
2017-04-17
Lead Sponsor
University of Washington
Target Recruit Count
3024
Registration Number
NCT01401647
Locations
🇺🇸

Alabama Resuscitation Center, Birmingham, Alabama, United States

🇺🇸

Portland Resuscitation Outcomes Consortium, Oregon Health & Sciences University, Portland, Oregon, United States

🇨🇦

University of Ottawa/University of British Columbia Collaborative RCC, Ottawa Health Research, Ottawa, Ontario, Canada

and more 6 locations

Lidocaine on Pain Relief and IL and Substance P in Fibromyalgia

Phase 3
Conditions
Interventions
First Posted Date
2011-07-12
Last Posted Date
2011-07-12
Lead Sponsor
Federal University of São Paulo
Target Recruit Count
40
Registration Number
NCT01391598
Locations
🇧🇷

Federal Unifesrity of Sao Paulo, Sao Paulo, Brazil

Subcutaneous Lidocaine For Cancer-Related Pain

Phase 2
Completed
Conditions
Interventions
First Posted Date
2011-06-29
Last Posted Date
2019-07-12
Lead Sponsor
British Columbia Cancer Agency
Target Recruit Count
33
Registration Number
NCT01384877
Locations
🇨🇦

BC Cancer Center of the North, Prince George, British Columbia, Canada

🇨🇦

BC Cancer Agency, Vancouver, British Columbia, Canada

Ultrasound Guided Blocks of the Iliohypogastric and Ilioinguinal Nerves in Persistent Postherniorrhaphy Pain Patients

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2011-06-15
Last Posted Date
2012-06-20
Lead Sponsor
Rigshospitalet, Denmark
Target Recruit Count
12
Registration Number
NCT01373593
Locations
🇩🇰

Rigshospitalet, Copenhagen, Denmark

Effect of Intravenous Lidocaine on the Tolerability of Early Oral Feeding After Laparoscopic Colorectal Surgery

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2011-05-03
Last Posted Date
2012-10-17
Lead Sponsor
Kangbuk Samsung Hospital
Target Recruit Count
77
Registration Number
NCT01346917
Locations
🇰🇷

Hyung Ook Kim, Seoul, Korea, Republic of

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