Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

A Comparison of Pain Severity on Injection of MCT/LCT Propofol Between Lidocaine 20 mg, 40 mg, and Without Lidocaine.

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2011-05-02
Last Posted Date
2011-05-02
Lead Sponsor
Prince of Songkla University
Target Recruit Count
210
Registration Number
NCT01345981
Locations
🇹🇭

Songklanagarind Hospital, Hatyai, Songkhla, Thailand

Topical Jelly and Intracameral Anesthesia Versus Subtenon Anesthesia, in Cataract Surgery

Phase 4
Withdrawn
Conditions
Interventions
First Posted Date
2011-04-29
Last Posted Date
2023-03-06
Lead Sponsor
Hospital Italiano de Buenos Aires
Registration Number
NCT01344252
Locations
🇦🇷

Hospitalitaliano de buenos aires, Caba, Argentina

🇦🇷

Hospital Italiano de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina

Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol

First Posted Date
2011-04-27
Last Posted Date
2019-05-29
Lead Sponsor
University of Wisconsin, Madison
Target Recruit Count
200
Registration Number
NCT01342510
Locations
🇺🇸

University of Wisconsin Hospital and Clinics, Madison, Wisconsin, United States

Hydrocodone For Pain Control in First Trimester Surgical Abortion

First Posted Date
2011-04-07
Last Posted Date
2019-04-26
Lead Sponsor
Elizabeth Micks
Target Recruit Count
121
Registration Number
NCT01330459
Locations
🇺🇸

Planned Parenthood CW, Portland, Oregon, United States

🇺🇸

Oregon Health & Science University, Portland, Oregon, United States

Pertubation With Lignocaine in Endometriosis

First Posted Date
2011-04-06
Last Posted Date
2011-04-06
Lead Sponsor
Isifer AB
Target Recruit Count
42
Registration Number
NCT01329796
Locations
🇸🇪

Läkargruppen Victoria Söderhallarna 120, Stockholm, Sweden

🇸🇪

Karolinska Institute, Fertility Unit, K59 Karolinska University Hospital at Huddinge, Stockholm, Sweden

🇸🇪

Department of Gynaecology and Obstetrics Danderyd Hospital, Stockholm, Sweden

Comparison of Two Lidocaine Administration Techniques

Phase 4
Completed
Conditions
Interventions
First Posted Date
2011-04-06
Last Posted Date
2018-07-26
Lead Sponsor
University of Chicago
Target Recruit Count
481
Registration Number
NCT01330134
Locations
🇺🇸

The University of Chicago Medical Center, Chicago, Illinois, United States

Lidocaine 5% Plasters (Versatis® 5%) in Pediatric Neuropathic Pains and Vasoocclusive Sickle Cell Crisis Pains

First Posted Date
2011-03-14
Last Posted Date
2014-10-30
Lead Sponsor
Centre Leon Berard
Target Recruit Count
39
Registration Number
NCT01314300
Locations
🇫🇷

Centre Médico-chirurgical de Réadaptation des Massues, Lyon, France

🇫🇷

IHOP, Lyon, France

The Impact of Pain Scores on Intrauterine Lidocaine Versus Normal Saline Infusion at the Time of IUD Placement

Phase 4
Completed
Conditions
Interventions
First Posted Date
2011-03-09
Last Posted Date
2014-02-05
Lead Sponsor
Women's Health Care Clinic, Torrance, California
Target Recruit Count
40
Registration Number
NCT01311102
Locations
🇺🇸

Women's Health Care Clinic, Torrance, California, United States

Clinical Study to Evaluate the Effect of pH on Pain Upon Local Anesthetic Administration.

First Posted Date
2011-02-25
Last Posted Date
2017-04-11
Lead Sponsor
Massachusetts General Hospital
Target Recruit Count
29
Registration Number
NCT01304082
Locations
🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

A Trial Assessing The Association Between Type Of Local Anesthesia Treatment And Postoperative Pain In Patients In Having Undergone Arrhythmia Surgery

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2011-02-21
Last Posted Date
2019-07-10
Lead Sponsor
Baylor Research Institute
Target Recruit Count
300
Registration Number
NCT01300377
Locations
🇺🇸

Baylor Jack and Jane Heart and Vascular Institute, Dallas, Texas, United States

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