Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Intravenous Lidocaine Randomized Comparative Effectiveness Trial

Phase 4
Completed
Conditions
Interventions
First Posted Date
2017-10-03
Last Posted Date
2020-08-10
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
154
Registration Number
NCT03300674
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

Lidocaine Infusion On Hysteroscopic Media Versus Oral Diclofinac For Pain Relief During Outpatient Hysteroscopy

First Posted Date
2017-10-02
Last Posted Date
2017-10-02
Lead Sponsor
Ain Shams University
Target Recruit Count
44
Registration Number
NCT03298646
Locations
🇪🇬

Ain Shams maternity hospital, Cairo, Egypt

Dexmedetomidine Combined With Lidocaine Infusion Affect Inflammation Cytokines

First Posted Date
2017-09-08
Last Posted Date
2022-03-10
Lead Sponsor
Anqing Municipal Hospital
Target Recruit Count
160
Registration Number
NCT03276533
Locations
🇨🇳

Department of Anqing Hospital Anesthesiology, Anqing, Anhui, China

Lidocaine for Oxaliplatin-induced Neuropathy

First Posted Date
2017-08-18
Last Posted Date
2022-03-09
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
26
Registration Number
NCT03254394
Locations
🇺🇸

Washington University School of Medicine/Barnes Jewish Hospital, Saint Louis, Missouri, United States

Lidocaine-Ketamine for Management of Chronic Pain

Not Applicable
Conditions
Interventions
First Posted Date
2017-08-15
Last Posted Date
2017-08-15
Lead Sponsor
Hamilton Health Sciences Corporation
Target Recruit Count
72
Registration Number
NCT03249025

Painless Local Anaesthesia With Bicarbonate Admixture

First Posted Date
2017-08-03
Last Posted Date
2017-12-21
Lead Sponsor
University of Zurich
Target Recruit Count
48
Registration Number
NCT03238625
Locations
🇨🇭

University hospital, Department of Dermatology, Zürich, Zurich, Switzerland

Lidocaine and Food Intake

Phase 4
Completed
Conditions
Interventions
First Posted Date
2017-07-24
Last Posted Date
2018-08-01
Lead Sponsor
Maastricht University Medical Center
Target Recruit Count
26
Registration Number
NCT03227900
Locations
🇳🇱

Maastricht University Medical Centre, Maastricht, Limburg, Netherlands

Intravenous Lidocaine in Bariatric Surgery.

First Posted Date
2017-07-07
Last Posted Date
2017-07-14
Lead Sponsor
University Hospital, Caen
Target Recruit Count
180
Registration Number
NCT03211455
Locations
🇫🇷

University Hospital of Caen, Caen, France

Cystoscopy in Females: Is There a Difference Between Rigid and Flex Cystoscopy, and Does it Require Local Anasthesia?

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2017-07-06
Last Posted Date
2019-12-04
Lead Sponsor
Assaf-Harofeh Medical Center
Target Recruit Count
120
Registration Number
NCT03210038
Locations
🇮🇱

Assaf Harofe Medical Center, Be'er Ya'aqov, Israel

Treatment of Renal Colic in the Emergency Departement (ED).

First Posted Date
2017-06-27
Last Posted Date
2022-08-10
Lead Sponsor
University of Monastir
Target Recruit Count
600
Registration Number
NCT03199924
Locations
🇹🇳

Emergency department of university hospital Fattouma Bourguiba of Monastir Monastir, Monastir Tunisia, Monastir, Tunisia

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