Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Serum Opiorphin Level After Intraoperative Intravenous Lidocaine Infusion

Phase 1
Completed
Conditions
Interventions
First Posted Date
2018-04-18
Last Posted Date
2018-04-19
Lead Sponsor
Assiut University
Target Recruit Count
80
Registration Number
NCT03502395
Locations
🇪🇬

Assiut university faculty of medicine, Assiut, Egypt

Adjuncts to IVRA, a Comparison Between Ketorolac and Paracetamol

First Posted Date
2018-04-02
Last Posted Date
2020-07-24
Lead Sponsor
Assiut University
Target Recruit Count
60
Registration Number
NCT03485625
Locations
🇪🇬

Omar Ali, Assiut, Egypt

Systemic Lidocaine Infusion for Pain Control in Ventral Hernia

First Posted Date
2018-04-02
Last Posted Date
2021-02-01
Lead Sponsor
Carilion Clinic
Registration Number
NCT03484650
Locations
🇺🇸

Carilion Roanoke Memorial Hospital, Roanoke, Virginia, United States

Usefulness of Lidocaine in Oral and Maxillofacial Surgeries Under General Anesthesia for Pain Control After Operation

Phase 4
Completed
Conditions
Interventions
First Posted Date
2018-03-27
Last Posted Date
2019-04-09
Lead Sponsor
B.P. Koirala Institute of Health Sciences
Target Recruit Count
40
Registration Number
NCT03479320
Locations
🇳🇵

B. P. Koirala Institute of Health Sciences, Dharān Bāzār, Nepal

MAST Trial: Multi-modal Analgesic Strategies in Trauma

First Posted Date
2018-03-21
Last Posted Date
2021-06-18
Lead Sponsor
The University of Texas Health Science Center, Houston
Target Recruit Count
1561
Registration Number
NCT03472469
Locations
🇺🇸

The University of Texas Health Science Center at Houston, Houston, Texas, United States

Pain Prevention During Propofol Infusion in Pediatric: Hypnoanalgesia of the Hand Versus Lidocaine.

First Posted Date
2018-03-05
Last Posted Date
2020-11-12
Lead Sponsor
University Hospital, Toulouse
Target Recruit Count
100
Registration Number
NCT03453723
Locations
🇫🇷

Hôpital des enfants - Pôle Anesthésie-Réanimation., Toulouse, France

Penile Fracture: A Comparison of Erectile Function After Immediate Repair Versus Delayed Repair

First Posted Date
2018-02-28
Last Posted Date
2018-03-01
Lead Sponsor
Ministry of Health, Jamaica
Target Recruit Count
46
Registration Number
NCT03449940
Locations
🇯🇲

Kingston Public Hospital, Kingston, Jamaica

🇯🇲

University Hospital of the West Indies, Kingston, Jamaica

Pharmacokinetic Study of Nanoencapsulated Gel of Lidocaine, Prilocaine and Combination of Lidocaine and Prilocaine

First Posted Date
2018-02-22
Last Posted Date
2018-02-22
Lead Sponsor
Galeno Desenvolvimento de Pesquisas Clínicas
Target Recruit Count
48
Registration Number
NCT03441841
Locations
🇧🇷

Galeno Desenvolvimento de Pesquisas Clinicas Ltda. - ME, Campinas, SP, Brazil

Effectiveness of Sphenopalatine Ganglion Block for Post-Dural Puncture Headache

First Posted Date
2018-02-13
Last Posted Date
2022-06-15
Lead Sponsor
Milton S. Hershey Medical Center
Target Recruit Count
6
Registration Number
NCT03430531
Locations
🇺🇸

Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States

Ketamine Versus Lidocaine Nebulization for Awake Fiberoptic Intubation

Phase 4
Completed
Conditions
Interventions
First Posted Date
2018-01-30
Last Posted Date
2019-11-26
Lead Sponsor
Ain Shams University
Target Recruit Count
60
Registration Number
NCT03414879
Locations
🇪🇬

Ain Shams University hospitals, Cairo, Egypt

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