Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Safety and Efficacy of Addition of Hyaluronidase to Lidocaine and Bupivacaine in Scalp Nerves Block in Elective Craniotomy Operations, Comparative Study

First Posted Date
2018-01-26
Last Posted Date
2018-04-27
Lead Sponsor
Cairo University
Target Recruit Count
64
Registration Number
NCT03411330
Locations
🇪🇬

Ahmed Abdalla Mohamed, Cairo, Egypt

Wound Infiltration With Ketorolac Versus Lidocaine for Postoperative Analgesia After Total Abdominal Hysterectomy

First Posted Date
2018-01-09
Last Posted Date
2018-01-09
Lead Sponsor
Ain Shams University
Target Recruit Count
80
Registration Number
NCT03394001
Locations
🇪🇬

Ain Shams University hospitals, Cairo, Egypt

Ketamine, Lidocaine and Combination for Postoperative Analgesia in Open Liver Resection

First Posted Date
2018-01-05
Last Posted Date
2023-07-06
Lead Sponsor
Lawson Health Research Institute
Target Recruit Count
124
Registration Number
NCT03391427
Locations
🇨🇦

London Health Sciences Center, London, Ontario, Canada

Effect of Intraoperative Lidocaine Infusion on Intraoperative Isoflurane Requirements

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2017-12-29
Last Posted Date
2017-12-29
Lead Sponsor
Assiut University
Target Recruit Count
50
Registration Number
NCT03386565

Does Low-does Cervical Epidural Lidocaine Cause Transient Weakness?

First Posted Date
2017-12-26
Last Posted Date
2022-11-25
Lead Sponsor
University of Utah
Target Recruit Count
16
Registration Number
NCT03382925
Locations
🇺🇸

University of Utah Orthopaedic Center, Salt Lake City, Utah, United States

Comparative Trial Via Tranforaminal Approach Versus Epidural Catheter Via Interlaminar Approach

First Posted Date
2017-12-26
Last Posted Date
2022-11-25
Lead Sponsor
University of Utah
Target Recruit Count
120
Registration Number
NCT03382821
Locations
🇺🇸

University of Utah Orthopaedic Center, Salt Lake City, Utah, United States

Pain Alleviation of Forearm Fractures

First Posted Date
2017-12-19
Last Posted Date
2019-02-28
Lead Sponsor
Assiut University
Target Recruit Count
66
Registration Number
NCT03377907
Locations
🇪🇬

Faculty of Medicine, Assiut University, Assiut, Egypt

Effect of Nebulized Lidocaine on the Quality of Laryngeal Mask Airway Insertion

First Posted Date
2017-12-04
Last Posted Date
2017-12-04
Lead Sponsor
Assiut University
Target Recruit Count
80
Registration Number
NCT03361397

Articaine vs Lidocaine for Pediatric Dental Procedures

First Posted Date
2017-10-24
Last Posted Date
2022-11-03
Lead Sponsor
Boston University
Registration Number
NCT03318952
Locations
🇺🇸

BU Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, United States

Pharmacokinetics of Lidocaine in Healthy Adults

First Posted Date
2017-10-16
Last Posted Date
2021-11-01
Lead Sponsor
Nicole K Brogden
Target Recruit Count
23
Registration Number
NCT03310970
Locations
🇺🇸

University of Iowa, Iowa City, Iowa, United States

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