Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients

First Posted Date
2017-06-06
Last Posted Date
2020-10-22
Lead Sponsor
Washington University School of Medicine
Registration Number
NCT03177252

Lidocaine vs Ketorolac for Management of Renal Colic in the Emergency Department

Phase 4
Conditions
Interventions
First Posted Date
2017-05-02
Last Posted Date
2018-07-11
Lead Sponsor
The Brooklyn Hospital Center
Target Recruit Count
60
Registration Number
NCT03137498
Locations
🇺🇸

The Brooklyn Hospital Center, Brooklyn, New York, United States

Clinical Outcomes Mandible: Buffered 1% vs. Non-Buffered 1% Lidocaine

Phase 4
Completed
Conditions
Interventions
First Posted Date
2017-04-25
Last Posted Date
2019-02-06
Lead Sponsor
University of North Carolina, Chapel Hill
Target Recruit Count
24
Registration Number
NCT03127943
Locations
🇺🇸

UNC School of Dentistry, Chapel Hill, North Carolina, United States

OFA - Opioid Free Anesthesia

First Posted Date
2017-04-21
Last Posted Date
2017-04-21
Lead Sponsor
University of Parma
Target Recruit Count
64
Registration Number
NCT03124082
Locations
🇮🇹

University Hospital, Parma, Italy

Effect of Intravenous Lidocaine, Used to Attenuate Pain With Propofol Injection, on Defibrillation Threshold Testing

Phase 1
Terminated
Conditions
Interventions
First Posted Date
2017-04-17
Last Posted Date
2017-05-09
Lead Sponsor
Drexel University College of Medicine
Target Recruit Count
19
Registration Number
NCT03117166
Locations
🇺🇸

Hahnemann University Hospital, Philadelphia, Pennsylvania, United States

Buffered Lidocaine in Paracervical Blocks

Phase 4
Completed
Conditions
Interventions
First Posted Date
2017-04-11
Last Posted Date
2021-01-05
Lead Sponsor
University of Hawaii
Target Recruit Count
98
Registration Number
NCT03107754
Locations
🇺🇸

Womens Options Center, Honolulu, Hawaii, United States

Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine

First Posted Date
2017-03-30
Last Posted Date
2019-07-02
Lead Sponsor
Gil Yosipovitch
Target Recruit Count
13
Registration Number
NCT03096444
Locations
🇺🇸

University of Miami, Miami, Florida, United States

Comparative Study of Nonintubated Uniport Thoracoscopic Surgery Using Thoracic Paravertebral Nerve Block Versus Intercostal Nerve Block for Peripheral Solitary Pulmonary Nodule Patients

First Posted Date
2017-03-22
Last Posted Date
2020-05-07
Lead Sponsor
Shenzhen Third People's Hospital
Target Recruit Count
48
Registration Number
NCT03086213
Locations
🇨🇳

the Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China

Analgesic Efficacy of Ultrasound Guided Quadratus Lumborum Block During ESWL

Phase 4
Completed
Conditions
Interventions
First Posted Date
2017-03-15
Last Posted Date
2017-11-14
Lead Sponsor
Ataturk University
Target Recruit Count
40
Registration Number
NCT03080363
Locations
🇹🇷

Ataturk University, Erzurum, Turkey

Corticosteroid Injection in Carpal Tunnel Syndrome

First Posted Date
2017-03-07
Last Posted Date
2019-07-30
Lead Sponsor
Taipei Veterans General Hospital, Taiwan
Target Recruit Count
56
Registration Number
NCT03072290
Locations
🇨🇳

Taipei veteran general hospital, Taipei, Taiwan

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