Methadone
- Generic Name
- Methadone
- Brand Names
- Diskets, Dolophine, Metadol, Metadol-D, Methadose
- Drug Type
- Small Molecule
- Chemical Formula
- C21H27NO
- CAS Number
- 76-99-3
- Unique Ingredient Identifier
- UC6VBE7V1Z
- Background
Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a number of uniqu...
- Indication
Methadone is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate. It's recommended that use is reserved for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwis...
- Associated Conditions
- Opioid Addiction, Severe Pain
- Associated Therapies
- Opioid Detoxification, Maintenance therapy
Role of Methadone As Co-Opioid Analgesic
- First Posted Date
- 2007-11-15
- Last Posted Date
- 2016-04-05
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 5
- Registration Number
- NCT00558870
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Buprenorphine Maintenance for Opioid-Addicted Persons in Jail and Post-Release
- First Posted Date
- 2006-08-22
- Last Posted Date
- 2013-05-01
- Target Recruit Count
- 116
- Registration Number
- NCT00367302
Opioid Rotation From Morphine to Methadone in Treatment of Non-malignant Pain
- First Posted Date
- 2006-07-25
- Last Posted Date
- 2016-07-29
- Lead Sponsor
- Norwegian University of Science and Technology
- Target Recruit Count
- 12
- Registration Number
- NCT00356083
Methadone Maintenance & HIV Risk in Ukraine
- First Posted Date
- 2006-07-12
- Last Posted Date
- 2016-09-07
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 50
- Registration Number
- NCT00351026
- Locations
- 🇺🇦
Kiev City AIDS Center, Kiev, Ukraine
🇺🇦City AIDS Center, Kiev, Ukraine
Starting Treatment With Agonist Replacement Therapies (START)
- Conditions
- Interventions
- First Posted Date
- 2006-04-18
- Last Posted Date
- 2017-01-06
- Lead Sponsor
- University of California, Los Angeles
- Target Recruit Count
- 1269
- Registration Number
- NCT00315341
- Locations
- 🇺🇸
Matrix Institute, Los Angeles, California, United States
🇺🇸BAART; Turk Street Clinic, San Francisco, California, United States
🇺🇸CODA-Research, Portland, Oregon, United States
A Stepwise Strategy Utilizing Buprenorphine and Methadone
- Conditions
- First Posted Date
- 2006-04-05
- Last Posted Date
- 2006-10-24
- Lead Sponsor
- Karolinska University Hospital
- Target Recruit Count
- 96
- Registration Number
- NCT00310934
- Locations
- 🇸🇪
Dept of Clinical Neuroscience, Karolinska Inst, Stockholm, Sweden
Treatment of Heroin and Cocaine With Methadone Maintenance and Contingency Management
- First Posted Date
- 2006-02-15
- Last Posted Date
- 2019-12-17
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Target Recruit Count
- 140
- Registration Number
- NCT00292110
- Locations
- 🇺🇸
National Institute on Drug Abuse, Baltimore, Maryland, United States
Combined Behavioral and Pharmacologic Treatment of Polydrug Abuse
- Conditions
- First Posted Date
- 2006-02-15
- Last Posted Date
- 2017-01-12
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Target Recruit Count
- 200
- Registration Number
- NCT00292123
Buprenorphine Versus Methadone Maintenance in Hepatitis C Patients Receiving Peg-Intron and Rebetol (Study P04279)(TERMINATED)
- Conditions
- First Posted Date
- 2006-01-19
- Last Posted Date
- 2012-11-22
- Lead Sponsor
- Indivior Inc.
- Target Recruit Count
- 128
- Registration Number
- NCT00279565
RCT Comparing Methadone and Buprenorphine in Pregnant Women
- Conditions
- Interventions
- First Posted Date
- 2005-12-30
- Last Posted Date
- 2015-08-05
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 175
- Registration Number
- NCT00271219
- Locations
- 🇺🇸
University of Vermont, Burlington, Vermont, United States
🇺🇸Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
🇺🇸Wayne State University, Detroit, Michigan, United States
Drug Development Updates
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