Methadone

Generic Name
Methadone
Brand Names
Diskets, Dolophine, Metadol, Metadol-D, Methadose
Drug Type
Small Molecule
Chemical Formula
C21H27NO
CAS Number
76-99-3
Unique Ingredient Identifier
UC6VBE7V1Z
Background

Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a number of uniqu...

Indication

Methadone is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate. It's recommended that use is reserved for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwis...

Associated Conditions
Opioid Addiction, Severe Pain
Associated Therapies
Opioid Detoxification, Maintenance therapy
Clinical Trials
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