Methadone
- Generic Name
- Methadone
- Brand Names
- Diskets, Dolophine, Metadol, Metadol-D, Methadose
- Drug Type
- Small Molecule
- Chemical Formula
- C21H27NO
- CAS Number
- 76-99-3
- Unique Ingredient Identifier
- UC6VBE7V1Z
- Background
Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a number of uniqu...
- Indication
Methadone is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate. It's recommended that use is reserved for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwis...
- Associated Conditions
- Opioid Addiction, Severe Pain
- Associated Therapies
- Opioid Detoxification, Maintenance therapy
Phase III Randomized Controlled Study of Morphine and Nortriptyline in the Management of Postherpetic Neuralgia
- Conditions
- First Posted Date
- 1999-10-19
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 120
- Registration Number
- NCT00004390
Cocaine Effects in Humans: Physiology and Behavior - 1
- Conditions
- First Posted Date
- 1999-09-21
- Last Posted Date
- 2017-01-12
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Target Recruit Count
- 19
- Registration Number
- NCT00000200
- Locations
- 🇺🇸
Columbia University, New York, New York, United States
Combining Behavioral Treatment With Agonist Maintenance - 1
- Conditions
- Interventions
- First Posted Date
- 1999-09-21
- Last Posted Date
- 2018-01-17
- Lead Sponsor
- Yale University
- Target Recruit Count
- 168
- Registration Number
- NCT00000311
- Locations
- 🇺🇸
APT Residential Services Division, New Haven, Connecticut, United States
Drug Development Updates
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