Methadone
- Generic Name
- Methadone
- Brand Names
- Diskets, Dolophine, Metadol, Metadol-D, Methadose
- Drug Type
- Small Molecule
- Chemical Formula
- C21H27NO
- CAS Number
- 76-99-3
- Unique Ingredient Identifier
- UC6VBE7V1Z
- Background
Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a number of uniqu...
- Indication
Methadone is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate. It's recommended that use is reserved for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwis...
- Associated Conditions
- Opioid Addiction, Severe Pain
- Associated Therapies
- Opioid Detoxification, Maintenance therapy
Methadone for Spinal Fusion Surgery.
- Conditions
- Interventions
- First Posted Date
- 2021-02-21
- Last Posted Date
- 2024-11-25
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 114
- Registration Number
- NCT04764825
- Locations
- 🇩🇰
Aarhus University Hospital, Aarhus, Denmark
Intraoperative Methadone for Postoperative Pain Control After Thoracic Surgery
- First Posted Date
- 2020-08-25
- Last Posted Date
- 2021-12-21
- Lead Sponsor
- NorthShore University HealthSystem
- Target Recruit Count
- 40
- Registration Number
- NCT04525898
- Locations
- 🇺🇸
NorthShore University HealthSystem, Evanston, Illinois, United States
Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1
- First Posted Date
- 2020-07-21
- Last Posted Date
- 2024-07-11
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 225
- Registration Number
- NCT04480554
- Locations
- 🇻🇳
Go Vap Clinic, Ho Chi Minh City, Vietnam
🇺🇸University of Pennsylvania, Philadelphia, Pennsylvania, United States
Methadone in Cystectomy Patients
- First Posted Date
- 2020-07-17
- Last Posted Date
- 2023-09-13
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 114
- Registration Number
- NCT04475029
- Locations
- 🇩🇰
Aarhus University Hospital, Aarhus, Denmark
Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS)
- Conditions
- Interventions
- First Posted Date
- 2020-01-02
- Last Posted Date
- 2024-02-28
- Target Recruit Count
- 190
- Registration Number
- NCT04214834
- Locations
- 🇺🇸
Loma Linda University Medical Center, Loma Linda, California, United States
🇺🇸University of Arizona, Tucson, Arizona, United States
🇺🇸West Virginia University Hospital, Morgantown, West Virginia, United States
Cognitive Function and Pain Threshold in People Who Are Methadone Maintained
- First Posted Date
- 2019-07-19
- Last Posted Date
- 2021-07-20
- Lead Sponsor
- Yale University
- Target Recruit Count
- 27
- Registration Number
- NCT04027166
- Locations
- 🇺🇸
Veteran Affairs Hospital, West Haven, Connecticut, United States
Effect of Heroin Use on Immune Activation and Cardiovascular Risk in HIV
- First Posted Date
- 2019-06-05
- Last Posted Date
- 2023-10-02
- Lead Sponsor
- MetroHealth Medical Center
- Target Recruit Count
- 190
- Registration Number
- NCT03976258
- Locations
- 🇺🇸
University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States
🇺🇸Metrohealth Medical center, Cleveland, Ohio, United States
Slow-Release Oral Morphine for the Treatment of Opioid Use Disorder
- Conditions
- Interventions
- First Posted Date
- 2019-05-14
- Last Posted Date
- 2022-02-10
- Lead Sponsor
- M. Eugenia Socias
- Target Recruit Count
- 27
- Registration Number
- NCT03948464
- Locations
- 🇨🇦
BCCSU Cordova Office, Vancouver, British Columbia, Canada
Postoperative Pain and Headache After Craniotomy
- First Posted Date
- 2019-04-09
- Last Posted Date
- 2020-06-12
- Lead Sponsor
- Steven Edelstein
- Registration Number
- NCT03908944
- Locations
- 🇺🇸
Loyola Medical Center, Maywood, Illinois, United States
Clinical Effectiveness and Safety of Intraoperative Methadone in Patients Undergoing Laparoscopic Hysterectomy
- Conditions
- Interventions
- First Posted Date
- 2019-04-09
- Last Posted Date
- 2022-11-02
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 126
- Registration Number
- NCT03908060
- Locations
- 🇩🇰
Department of Anaesthesiology and Intensive Care, Horsens Regional Hospital, Horsens, Central Denmark Region, Denmark
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.