Methadone

Generic Name
Methadone
Brand Names
Diskets, Dolophine, Metadol, Metadol-D, Methadose
Drug Type
Small Molecule
Chemical Formula
C21H27NO
CAS Number
76-99-3
Unique Ingredient Identifier
UC6VBE7V1Z
Background

Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a number of uniqu...

Indication

Methadone is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate. It's recommended that use is reserved for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwis...

Associated Conditions
Opioid Addiction, Severe Pain
Associated Therapies
Opioid Detoxification, Maintenance therapy
Clinical Trials
Related News

Methadone and Interscalene Block for Shoulder Surgery

First Posted Date
2017-03-21
Last Posted Date
2020-08-25
Lead Sponsor
NorthShore University HealthSystem
Target Recruit Count
100
Registration Number
NCT03084588
Locations
🇺🇸

NorthShore University HealthSystem, Evanston, Illinois, United States

QUALITY OF RECOVERY AFTER INTRAOPERATIVE MORPHINE OR METHADONE

First Posted Date
2017-02-07
Last Posted Date
2017-05-08
Lead Sponsor
Pontificia Universidade Catolica de Sao Paulo
Target Recruit Count
70
Registration Number
NCT03045133
Locations
🇧🇷

Santa Lucinda Hospital, Sorocaba, SP, Brazil

A Pragmatic Randomized Control Trial Comparing Models of Care in the Management of Prescription Opioid Misuse

First Posted Date
2017-01-27
Last Posted Date
2021-06-16
Lead Sponsor
Didier Jutras Aswad
Target Recruit Count
272
Registration Number
NCT03033732
Locations
🇨🇦

Edmonton Opioid Dependency Program, Edmonton, Alberta, Canada

🇨🇦

Addiction Medicine Service- Centre for Addictions and Mental Health, Toronto, Ontario, Canada

🇨🇦

Rapid Access Addictions Clinic-St. Paul's Hospital, Vancouver, British Columbia, Canada

and more 4 locations

Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

First Posted Date
2016-11-08
Last Posted Date
2017-03-20
Lead Sponsor
University of Illinois College of Medicine at Peoria
Target Recruit Count
80
Registration Number
NCT02958566
Locations
🇺🇸

Uicomp, Peoria, Illinois, United States

Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome

Phase 4
Completed
Conditions
Neonatal Abstinence Syndrome
Interventions
Drug: Morphine
Drug: Methadone
First Posted Date
2016-08-01
Last Posted Date
2023-05-24
Lead Sponsor
University of New Mexico
Target Recruit Count
61
Registration Number
NCT02851303
Locations
🇺🇸

University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States

Preoperative Oral Methadone for Patients Undergoing Cardiac Surgery: Reduction of Postoperative Pain

Phase 2
Completed
Conditions
Pain
Interventions
Drug: Placebo
Drug: Methadone
First Posted Date
2016-05-17
Last Posted Date
2018-01-02
Lead Sponsor
University of Saskatchewan
Target Recruit Count
21
Registration Number
NCT02774499
Locations
🇨🇦

Saskatoon Health Region, 410 22nd Street East, Saskatoon, Saskatchewan, Canada

Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery

Not Applicable
Terminated
Conditions
Opioid Use, Unspecified
Interventions
Drug: Fentanyl
Drug: Methadone
First Posted Date
2016-04-22
Last Posted Date
2021-06-01
Lead Sponsor
Andrew Waberski
Target Recruit Count
26
Registration Number
NCT02747875
Locations
🇺🇸

Children's National Health System, Washington, District of Columbia, United States

Effects of Doravirine (MK-1439) on Methadone Pharmacokinetics in Methadone-Maintained Participants (MK-1439-045)

First Posted Date
2016-03-22
Last Posted Date
2019-06-25
Lead Sponsor
Merck Sharp & Dohme LLC
Target Recruit Count
14
Registration Number
NCT02715700

Comparative Evaluation of PUSPENs and C&Cs

Terminated
Conditions
Opioid-Related Disorders
Interventions
Drug: Methadone
First Posted Date
2016-03-03
Last Posted Date
2016-03-03
Lead Sponsor
University of Malaya
Target Recruit Count
281
Registration Number
NCT02698098

A Study to Assess the Drug-drug Interaction of BMS 663068 With Methadone and Also With Buprenorphine/Naloxone

First Posted Date
2016-01-28
Last Posted Date
2017-08-09
Lead Sponsor
ViiV Healthcare
Target Recruit Count
32
Registration Number
NCT02666001
Locations
🇺🇸

GSK Investigational Site, Overland Park, Kansas, United States

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