Methadone

Generic Name
Methadone
Brand Names
Diskets, Dolophine, Metadol, Metadol-D, Methadose
Drug Type
Small Molecule
Chemical Formula
C21H27NO
CAS Number
76-99-3
Unique Ingredient Identifier
UC6VBE7V1Z
Background

Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a number of uniqu...

Indication

Methadone is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate. It's recommended that use is reserved for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwis...

Associated Conditions
Opioid Addiction, Severe Pain
Associated Therapies
Opioid Detoxification, Maintenance therapy
Clinical Trials
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Not Applicable
Completed
Conditions
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Procedure: Automated recommendation at the start of the case
Procedure: Automated notification at the start of surgery
Procedure: Automated notification at the end of surgery
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Procedure: Elective surgery
Drug: Propofol
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Drug: Isoflurane
Drug: Desflurane
Drug: Scopolamine
Drug: Droperidol
Drug: Haloperidol
Drug: Dexamethasone
Drug: Promethazine
Drug: Meclizine
Drug: Aprepitant
Drug: Metoclopramide
Drug: Fentanyl
Drug: Sufentanil
Drug: Alfentanil
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Drug: Morphine
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Drug: Hydromorphone
Drug: Methadone
Drug: Oxycodone
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First Posted Date
2015-12-09
Last Posted Date
2019-03-07
Lead Sponsor
Vanderbilt University
Target Recruit Count
27034
Registration Number
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Locations
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Vanderbilt University Medical Center, Nashville, Tennessee, United States

Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients

First Posted Date
2015-09-23
Last Posted Date
2023-11-18
Lead Sponsor
Medical College of Wisconsin
Target Recruit Count
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Registration Number
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Comparing Opium Tincture (OT) With Methadone for Medication-assisted Treatment of Opioid Use Disorder

Phase 3
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Conditions
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Drug: methadone
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First Posted Date
2015-07-20
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Registration Number
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Rooz-e-No substance use treatment center, Shiraz, Iran, Islamic Republic of

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Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management

Phase 4
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Conditions
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First Posted Date
2015-01-09
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2015-01-09
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Registration Number
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Siriraj Hospital, Bangkoknoi, Bangkok, Thailand

A Randomized Trial of Interim Methadone and Patient Navigation Initiated in Jail

First Posted Date
2015-01-08
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225
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Baltimore City Detention Center, Baltimore, Maryland, United States

Methadone in Ambulatory Surgery

First Posted Date
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13
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Cedars Sinai Medical Center, Los Angeles, California, United States

Study of Tipranavir and Ritonavir on the Pharmacokinetic Characteristics of Methadone Administered in Healthy Volunteers

Phase 1
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Conditions
Healthy
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Drug: Tipranavir
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First Posted Date
2014-09-19
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2014-09-19
Lead Sponsor
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15
Registration Number
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Methadone and Ketamine for Neuropathic Pain Treatment

First Posted Date
2014-09-08
Last Posted Date
2014-09-08
Lead Sponsor
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Target Recruit Count
37
Registration Number
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Locations
🇧🇷

University Hospital in Santa Maria, Santa Maria, Rio Grande do Sul, Brazil

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