Methadone
- Generic Name
- Methadone
- Brand Names
- Diskets, Dolophine, Metadol, Metadol-D, Methadose
- Drug Type
- Small Molecule
- Chemical Formula
- C21H27NO
- CAS Number
- 76-99-3
- Unique Ingredient Identifier
- UC6VBE7V1Z
- Background
Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a number of uniqu...
- Indication
Methadone is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate. It's recommended that use is reserved for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwis...
- Associated Conditions
- Opioid Addiction, Severe Pain
- Associated Therapies
- Opioid Detoxification, Maintenance therapy
The Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome
- First Posted Date
- 2012-12-21
- Last Posted Date
- 2014-06-13
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Target Recruit Count
- 20
- Registration Number
- NCT01754324
- Locations
- 🇺🇸
The University Hospital, Cincinnati, Ohio, United States
🇺🇸Mercy Hospital Anderson, Cincinnati, Ohio, United States
Methadone in Post-Herpetic Neuralgia Pain
- First Posted Date
- 2012-12-19
- Last Posted Date
- 2013-03-18
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 10
- Registration Number
- NCT01752699
Neurocognitive Effects of Opiate Agonist Treatment
- Conditions
- Interventions
- First Posted Date
- 2012-11-27
- Last Posted Date
- 2022-02-11
- Lead Sponsor
- Albert Einstein College of Medicine
- Target Recruit Count
- 135
- Registration Number
- NCT01733693
- Locations
- 🇺🇸
Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, United States
🇺🇸Fordham University, Bronx, New York, United States
Diversion to Treatment for Injection Drug Users Arrested for Possession of Heroin
- Conditions
- Interventions
- First Posted Date
- 2012-11-08
- Last Posted Date
- 2014-12-11
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 1
- Registration Number
- NCT01723527
- Locations
- 🇺🇸
Center for Learning and Health, Baltimore, Maryland, United States
Treatment of Neonatal Abstinence Syndrome
- Conditions
- Interventions
- First Posted Date
- 2012-11-08
- Last Posted Date
- 2013-11-27
- Lead Sponsor
- Eastern Maine Medical Center
- Target Recruit Count
- 40
- Registration Number
- NCT01723722
- Locations
- 🇺🇸
Eastern Maine Medical Center, Bangor, Maine, United States
Pharmacogenomics of Methadone in Spine Fusion Surgery
- First Posted Date
- 2012-09-03
- Last Posted Date
- 2015-04-22
- Lead Sponsor
- Northwestern University
- Registration Number
- NCT01677650
- Locations
- 🇺🇸
Northwestern Memorial Hospital, Chicago, Illinois, United States
Drug Interaction Study of Isavuconazole and Methadone
- Conditions
- Interventions
- First Posted Date
- 2012-04-20
- Last Posted Date
- 2012-07-02
- Lead Sponsor
- Astellas Pharma Global Development, Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT01582425
- Locations
- 🇺🇸
Parexel International, LLC, Glendale, California, United States
Efficacy Evaluation of Traditional Chinese Medicine JITAI Combined Comprehensive Model Among Heroin Addicts After Detoxification
- Conditions
- Interventions
- First Posted Date
- 2012-04-18
- Last Posted Date
- 2015-11-18
- Lead Sponsor
- Shanghai Mental Health Center
- Target Recruit Count
- 554
- Registration Number
- NCT01580163
- Locations
- 🇨🇳
National Institute on Drug Dependence，Peking University, Beijing, Beijing, China
🇨🇳The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
Reducing Drug Use and HIV Risk in Drug-dependent Adults Arrested for Prostitution
- Conditions
- Interventions
- First Posted Date
- 2012-03-22
- Last Posted Date
- 2014-12-11
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 38
- Registration Number
- NCT01560221
- Locations
- 🇺🇸
The Center for Learning and Health, Baltimore, Maryland, United States
Buprenorphine and Methadone for Opioid-dependent Chronic Back Pain Patients
- First Posted Date
- 2012-03-21
- Last Posted Date
- 2020-11-03
- Lead Sponsor
- State University of New York at Buffalo
- Target Recruit Count
- 19
- Registration Number
- NCT01559454
- Locations
- 🇺🇸
UB/MD Family Medicine, Inc., Amherst, New York, United States
Drug Development Updates
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