Methadone
- Generic Name
- Methadone
- Brand Names
- Diskets, Dolophine, Metadol, Metadol-D, Methadose
- Drug Type
- Small Molecule
- Chemical Formula
- C21H27NO
- CAS Number
- 76-99-3
- Unique Ingredient Identifier
- UC6VBE7V1Z
- Background
Methadone is a potent synthetic analgesic that works as a full ยต-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a number of uniqu...
- Indication
Methadone is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate. It's recommended that use is reserved for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwis...
- Associated Conditions
- Opioid Addiction, Severe Pain
- Associated Therapies
- Opioid Detoxification, Maintenance therapy
A Trial Comparing Single Intra-op Dose of Methadone Versus Placebo in Patients Undergoing Spine Surgery
- First Posted Date
- 2014-08-01
- Last Posted Date
- 2021-02-16
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 74
- Registration Number
- NCT02206685
- Locations
- ๐บ๐ธ
Texas Children's Hospital, Houston, Texas, United States
Methadone and Hydromorphone For Spinal Surgery
- Conditions
- Interventions
- First Posted Date
- 2014-04-08
- Last Posted Date
- 2019-09-30
- Lead Sponsor
- NorthShore University HealthSystem
- Target Recruit Count
- 120
- Registration Number
- NCT02107339
- Locations
- ๐บ๐ธ
NorthShore University HealthSystem, Evanston, Illinois, United States
Drug Interaction & Methadone & Buprenorphine
- Conditions
- Interventions
- First Posted Date
- 2014-01-27
- Last Posted Date
- 2014-06-17
- Lead Sponsor
- Bristol-Myers Squibb
- Target Recruit Count
- 32
- Registration Number
- NCT02045693
- Locations
- ๐บ๐ธ
Cri Lifetree, Philadelphia, Pennsylvania, United States
๐บ๐ธAnaheim Clinical Trials Llc, Anaheim, California, United States
๐บ๐ธLifetree Clinical Research, Salt Lake City, Utah, United States
Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit
- Conditions
- Interventions
- First Posted Date
- 2014-01-01
- Last Posted Date
- 2014-01-17
- Lead Sponsor
- Henry Ford Health System
- Target Recruit Count
- 46
- Registration Number
- NCT02025855
- Locations
- ๐บ๐ธ
Henry Ford Hospital, Detroit, Michigan, United States
Improving Outcomes in Neonatal Abstinence Syndrome
- Conditions
- Interventions
- First Posted Date
- 2013-10-09
- Last Posted Date
- 2019-10-15
- Lead Sponsor
- Tufts Medical Center
- Target Recruit Count
- 117
- Registration Number
- NCT01958476
- Locations
- ๐บ๐ธ
Baystate Medical Center, Springfield, Massachusetts, United States
๐บ๐ธShands Jacksonville Medical Center, Jacksonville, Florida, United States
๐บ๐ธBoston Medical Center, Boston, Massachusetts, United States
Pharmacokinetics of Multiple Dose Methadone in Children Treated for Opiate Withdrawal
- First Posted Date
- 2013-09-19
- Last Posted Date
- 2018-12-24
- Lead Sponsor
- Kevin Watt
- Target Recruit Count
- 26
- Registration Number
- NCT01945736
- Locations
- ๐บ๐ธ
Duke University Medical Center, Durham, North Carolina, United States
๐บ๐ธC.S. Mott Children's Hospital, Ann Arbor, Michigan, United States
๐บ๐ธAll Children's Hospital, Saint Petersburg, Florida, United States
Prospective Longitudinal Observational Study to Evaluate the Clinical Characteristics and Opioids Treatments in Patients With Breakthrough Cancer Pain
- First Posted Date
- 2013-09-19
- Last Posted Date
- 2016-04-14
- Target Recruit Count
- 150
- Registration Number
- NCT01946555
- Locations
- ๐ฎ๐น
A.O. Universitaria Parma, Parma, Italia, Italy
๐ฎ๐นOspedale di Piacenza, Piacenza, Italy
๐ฎ๐นOspedale Magati, Scandiano, Italia, Italy
Methadone for Postoperative Pain
- Conditions
- Interventions
- First Posted Date
- 2013-04-17
- Last Posted Date
- 2023-09-26
- Lead Sponsor
- Universidad de Valparaiso
- Target Recruit Count
- 86
- Registration Number
- NCT01833715
- Locations
- ๐จ๐ฑ
Almirante Nef Naval Hospital, Viรฑa del Mar, Valparaiso, Chile
Comparison Between Methadone and Morphine for Neonatal Opiate Withdrawal
- First Posted Date
- 2013-03-05
- Last Posted Date
- 2017-09-28
- Lead Sponsor
- Eastern Maine Medical Center
- Target Recruit Count
- 31
- Registration Number
- NCT01804075
Evaluation of the Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer-related Pain With Inadequate Pain Relief or Intolerable Side Effects When Treated With Level 3 Opioids.
- First Posted Date
- 2013-02-15
- Last Posted Date
- 2024-10-31
- Lead Sponsor
- Laboratoires Bouchara-Recordati
- Target Recruit Count
- 146
- Registration Number
- NCT01793480
- Locations
- ๐ซ๐ท
Investigational Site 10, Amiens, France
๐ซ๐ทInvestigational Site 06, Bayonne, France
๐ซ๐ทInvestigational Site 13, Caen, France
Drug Development Updates
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