Methadone

Generic Name: Methadone

Brand Names: Diskets, Dolophine, Metadol, Metadol-D, Methadose

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₇NO

CAS Number: 76-99-3

Unique Ingredient Identifier: UC6VBE7V1Z

Background: Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a number of uniqu...

Indication: Methadone is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate. It's recommended that use is reserved for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwis...

Associated Conditions: Opioid Addiction, Severe Pain

Associated Therapies: Opioid Detoxification, Maintenance therapy

Clinical Trials

Intraoperative Opioids and Postoperative Recovery After Hepatobiliary or Foregut Surgery

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Drug: Methadone
Drug: Hydromorphone

First Posted Date: 2012-03-07

Last Posted Date: 2021-12-21

Lead Sponsor: NorthShore University HealthSystem

Target Recruit Count: 60

Registration Number: NCT01546948

Locations: 🇺🇸
NorthShore University HealthSystem, Evanston, Illinois, United States

The Effect of Choice of Intraoperative Opioid on Postoperative Pain

Phase 4

Completed

Conditions: Pain, Postoperative
Chronic Pain

Interventions: Drug: Fentanyl
Drug: Methadone

First Posted Date: 2012-03-02

Last Posted Date: 2019-09-30

Lead Sponsor: NorthShore University HealthSystem

Target Recruit Count: 164

Registration Number: NCT01542645

Locations: 🇺🇸
NorthShore University HealthSystem, Evanston, Illinois, United States

Methadone-Dolutegravir (DTG - GSK1349572) Drug Interaction Study.

Phase 1

Completed

Conditions: Infections, Human Immunodeficiency Virus and Hepatitis

Interventions: Drug: Methadone
Drug: Dolutegravir

First Posted Date: 2011-11-08

Last Posted Date: 2012-04-09

Lead Sponsor: ViiV Healthcare

Target Recruit Count: 11

Registration Number: NCT01467518

Locations: 🇨🇦
GSK Investigational Site, Toronto, Ontario, Canada

Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia

Not Applicable

Terminated

Conditions: Pain, Postoperative

Interventions: Drug: Methadone
Drug: Morphine

First Posted Date: 2011-09-08

Last Posted Date: 2016-04-04

Lead Sponsor: Baylor College of Medicine

Target Recruit Count: 17

Registration Number: NCT01430182

Locations: 🇺🇸
Ben Taub General Hospital, Houston, Texas, United States

A Study to Evaluate the Pharmacokinetic Effect of SCH 503034 (Boceprevir) on Methadone or Buprenorphine/Naloxone Plasma Concentrations (P08123)

Phase 1

Completed

Conditions: Hepatitis C Virus

Interventions: Drug: boceprevir
Drug: methadone
Drug: buprenorphine/naloxone

First Posted Date: 2011-07-18

Last Posted Date: 2017-04-07

Lead Sponsor: Merck Sharp & Dohme LLC

Target Recruit Count: 21

Registration Number: NCT01396005

A Study on the Interaction Between Danoprevir/Ritonavir and Methadone

Phase 1

Completed

Conditions: Healthy Volunteer

Interventions: Drug: danoprevir
Drug: methadone
Drug: ritonavir

First Posted Date: 2011-07-08

Last Posted Date: 2016-11-02

Lead Sponsor: Hoffmann-La Roche

Target Recruit Count: 18

Registration Number: NCT01389544

The Use of Methadone in Newborn Infants

Phase 1

Completed

Conditions: Premature Birth of Newborn
Critically Ill

Interventions: Drug: Methadone

First Posted Date: 2011-04-01

Last Posted Date: 2018-07-26

Lead Sponsor: John van den Anker

Target Recruit Count: 60

Registration Number: NCT01327079

Locations: 🇺🇸
Childrens Research Institute, Washington, District of Columbia, United States
🇺🇸
Childrens's Research Institute, Washington, District of Columbia, United States

Treatment of Pain in Head-and-Neck Cancer Patients: is Methadone More Effective?

Phase 4

Completed

Conditions: Pain
Cancer of Head and Neck

Interventions: Drug: fentanyl
Drug: methadone

First Posted Date: 2011-03-17

Last Posted Date: 2015-07-16

Lead Sponsor: Maastricht University Medical Center

Target Recruit Count: 134

Registration Number: NCT01317589

Locations: 🇳🇱
University Hospital Maastricht, Maastricht, Netherlands

Methadone in Neuropathic Pain

Phase 4

Terminated

Conditions: Chronic Neuropathic Pain

Interventions: Drug: Controlled Release Morphine
Drug: Methadone

First Posted Date: 2010-09-20

Last Posted Date: 2021-01-28

Lead Sponsor: Nova Scotia Health Authority

Target Recruit Count: 14

Registration Number: NCT01205516

Locations: 🇨🇦
QEII Health Science Centre Pain Management Unit, Halifax, Nova Scotia, Canada
🇨🇦
Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, Quebec, Canada
🇨🇦
St. Joseph's Health Care Centre, Neuropathic Pain Clinic, London, Ontario, Canada

IRB-HSR# 14145 R,S Methadone: Analgesia and Pharmacokinetics in Adolescents Undergoing Scoliosis Correction

Phase 3

Completed

Conditions: Scoliosis

Interventions: Drug: methadone

First Posted Date: 2010-09-20

Last Posted Date: 2016-03-03

Lead Sponsor: University of Virginia

Target Recruit Count: 11

Registration Number: NCT01205256

Locations: 🇺🇸
University of Virginia Health System, Charlottesville, Virginia, United States

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