Overview
Desflurane, or I-653, a a volatile anesthetic that is more rapidly cleared and less metabolized than previous inhaled anesthetics such as methoxyflurane, sevoflurane, enflurane, or isoflurane.. It was developed in the late 1980s out of a need for a more rapidly acting and rapidly cleared inhaled anesthetic. Desflurane was granted FDA approval on 18 September 1992.
Background
Desflurane, or I-653, a a volatile anesthetic that is more rapidly cleared and less metabolized than previous inhaled anesthetics such as methoxyflurane, sevoflurane, enflurane, or isoflurane.. It was developed in the late 1980s out of a need for a more rapidly acting and rapidly cleared inhaled anesthetic. Desflurane was granted FDA approval on 18 September 1992.
Indication
Desflurane is indicated for the induction and maintenance of anesthesia in adults, as well as the maintenance of anesthesia in pediatric patients.
Associated Conditions
No associated conditions information available.
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2025/06/11 | Not Applicable | Recruiting | |||
2025/01/17 | Phase 4 | Not yet recruiting | Georgia Tsaousi | ||
2025/01/13 | Not Applicable | Not yet recruiting | Xiaguang Duan | ||
2024/06/13 | Phase 4 | Withdrawn | Kocaeli City Hospital | ||
2024/02/09 | Not Applicable | Not yet recruiting | |||
2024/02/05 | Early Phase 1 | Not yet recruiting | Sichuan Provincial People's Hospital | ||
2023/12/19 | Not Applicable | Recruiting | |||
2023/11/09 | Not Applicable | Not yet recruiting | Ajou University School of Medicine | ||
2023/09/06 | N/A | Completed | Recep Tayyip Erdogan University | ||
2023/08/14 | Phase 4 | Recruiting |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Henry Schein, Inc. | 0404-9961 | RESPIRATORY (INHALATION) | 240 mL in 240 mL | 11/16/2023 | |
| General Injectables & Vaccines, Inc | 52584-641 | RESPIRATORY (INHALATION) | 240 mL in 240 mL | 12/27/2022 | |
| Piramal Critical Care Inc | 66794-021 | RESPIRATORY (INHALATION) | 250 mL in 250 mL | 2/28/2023 | |
| Baxter Healthcare Corporation | 10019-641 | RESPIRATORY (INHALATION) | 240 mL in 240 mL | 2/22/2023 | |
| Baxter Healthcare Corporation | 10019-644 | RESPIRATORY (INHALATION) | 240 mL in 240 mL | 2/26/2015 | |
| Baxter Healthcare Corporation | 10019-646 | RESPIRATORY (INHALATION) | 240 mL in 240 mL | 2/26/2015 | |
| Sandoz Inc. | 0781-6172 | RESPIRATORY (INHALATION) | 240 mL in 240 mL | 11/8/2022 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| SUPRANE INHALATION ANAESTHETIC | SIN08818P | SOLUTION | 100% | 8/6/1996 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Desflurane | 国药准字H20168004 | 化学药品 | 原料药 | 3/26/2021 | |
| Desflurane | 国药准字HJ20170089 | 化学药品 | 溶液剂 | 3/1/2024 | |
| Desflurane | 国药准字H20100010 | 化学药品 | 原料药 | 10/23/2019 | |
| Desflurane | 国药准字H20143157 | 化学药品 | 原料药 | 8/6/2024 | |
| Desflurane | 国药准字H20130120 | 化学药品 | 原料药 | 10/15/2023 | |
| Desflurane | 国药准字H20113167 | 化学药品 | N/A | 5/10/2021 | |
| Desflurane | 国药准字H20100054 | 化学药品 | 原料药 | 4/8/2020 | |
| Desflurane | 国药准字H20100059 | 化学药品 | 原料药 | 9/30/2024 | |
| Desflurane, Liquid for Inhalation | 国药准字H20183269 | 化学药品 | 吸入制剂 | 4/12/2023 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| Suprane | 162790 | Medicine | A | 6/25/2009 | |
| DESFLURANE SANDOZ desflurane 1 mL/mL inhalation bottle | 286615 | Medicine | A | 3/12/2020 | |
| SUPRANE desflurane 1g/g inhalation USP bottle | 60909 | Medicine | A | 8/20/1997 | |
| PIRAMAL DESFLURANE desflurane 1 mL/mL inhalation bottle | 314700 | Medicine | A | 1/21/2020 |