Pseudoephedrine

Generic Name: Pseudoephedrine

Brand Names: Advil Cold and Sinus, Alavert D, Aleve-D, Allegra-D, Aller-tec D, Allerclear, Bromfed DM, Cheratussin Dac, Clarinex-D, Claritin-D, Codar D, Covan, Entex T, Lodrane D, Mar-cof BP, Mucinex D, Nexafed, Pseudodine C, Rescon Tablets, Semprex-D, Stahist Ad Liquid, Sudafed, Sudafed Sinus & Pain, Sudogest, Triacin-C, Tusnel C, Wal Zyr D, Wal-act, Wal-itin D, Wal-phed, Zephrex-D, Zyrtec-D

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₅NO

CAS Number: 90-82-4

Unique Ingredient Identifier: 7CUC9DDI9F

Background: Pseudoephedrine is structurally related to ephedrine but exerts a weaker effect on the sympathetic nervous system. Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseudoephedrine was described in dogs in 1927.

Indication: Pseudoephedrine is a sympathomimetic amine used for its decongestant activity.

Associated Conditions: Allergic Reaction, Allergic Rhinitis (AR), Common Cold, Common Cold Associated With Cough, Cough, Cough caused by Common Cold, Eye allergy, Fever, Flu caused by Influenza, Headache, Irritative cough, Nasal Allergies, Nasal Congestion, Nasal Congestion caused by Common Cold, Pain, Perennial Allergy, Priapism, Respiratory Allergy, Rhinorrhoea, Seasonal Allergic Rhinitis, Seasonal Allergies, Sinus Congestion, Sinusitis, Sneezing, Sore Throat, Symptoms of Acute Bronchitis Accompanied by Coughing, Throat irritation, Upper Respiratory Tract Infection, Upper respiratory tract congestion, Upper respiratory tract signs and symptoms, Cold or flu syndrome, Dry cough, Minor aches and pains, Sinus pain, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy

Clinical Trials

A Study of Continuous Blood Pressure Monitoring in Healthy Participants

Not Applicable

Completed

Conditions: Healthy

Interventions: Drug: Propranolol
Drug: Pseudoephedrine
Device: ABPM and Wearable Novel Devices
Other: No Intervention

First Posted Date: 2023-01-20

Last Posted Date: 2023-04-13

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 24

Registration Number: NCT05692869

Locations: 🇸🇬
Lilly Centre for Clinical Pharmacology, Singapore, Singapore

A Study of Continuous Heart Rate Monitoring in Healthy Participants

Not Applicable

Completed

Conditions: Healthy

Interventions: Drug: Propranolol
Drug: Pseudoephedrine
Device: Wearable Biosensor Patch Device

First Posted Date: 2020-12-23

Last Posted Date: 2021-04-19

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 21

Registration Number: NCT04682184

Locations: 🇸🇬
Lilly Centre for Clinical Pharmacology, Singapore, Singapore

Drug-drug Interaction Study of Ozanimod With Pseudoephedrine to Evaluate the Effect on Blood Pressure and Heart Rate

Phase 1

Completed

Conditions: Healthy Volunteers

Interventions: Drug: ozanimod
Drug: ozanimod placebo
Drug: Pseudoephedrine

First Posted Date: 2018-08-23

Last Posted Date: 2019-05-30

Lead Sponsor: Celgene

Target Recruit Count: 54

Registration Number: NCT03644576

Locations: 🇺🇸
ICON Early Phase Services, San Antonio, Texas, United States

Epinastine + Pseudoephedrine SR (Slow Release) Versus Epinastine Alone in Patients With Perennial Allergic Rhinitis

Phase 3

Completed

Conditions: Rhinitis, Allergic, Perennial

Interventions: Drug: Epinastine
Drug: Pseudoephedrine
Drug: Placebo

First Posted Date: 2014-07-08

Last Posted Date: 2014-07-14

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 101

Registration Number: NCT02182518

Epinastine and Pseudoephedrine Fixed Combination Compared to Separate Administration in Healthy Volunteers

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Epinastine
Drug: Pseudoephedrine
Drug: Epinastine + Pseudoephedrine combination

First Posted Date: 2014-07-08

Last Posted Date: 2014-07-14

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 25

Registration Number: NCT02182531

TransMEM Gas Exchange -- Project 1, Aim 2

Phase 1

Completed

Conditions: Middle Ear Disease
Nasal Allergy

Interventions: Biological: ragweed
Biological: histamine
Drug: pseudoephedrine
Drug: Oxymetazoline

First Posted Date: 2013-08-20

Last Posted Date: 2020-02-07

Lead Sponsor: Cuneyt M. Alper

Target Recruit Count: 84

Registration Number: NCT01925729

Locations: 🇺🇸
Middle Ear Physiology Laboratory, University of PIttsburgh, Pittsburgh, Pennsylvania, United States

Fexofenadine HCL - Pseudoephedrine HCL Combination Versus Allegra in Patients With Seasonal Allergic Rhinitis

Phase 3

Completed

Conditions: Rhinitis Seasonal

Interventions: Drug: fexofenadine HCL (M016455)
Drug: pseudoephedrine
Drug: fexofenadine HCL matching placebo
Drug: pseudoephedrine matching placebo

First Posted Date: 2011-03-02

Last Posted Date: 2013-10-16

Lead Sponsor: Sanofi

Target Recruit Count: 520

Registration Number: NCT01306721

Locations: 🇯🇵
Investigational Site Number 392003, Osaka-Shi, Japan
🇯🇵
Investigational Site Number 392001, Shinjuku-Ku, Japan
🇯🇵
Investigational Site Number 392002, Koganei-Shi, Japan