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Pseudoephedrine

Generic Name
Pseudoephedrine
Brand Names
Advil Cold and Sinus, Alavert D, Aleve-D, Allegra-D, Aller-tec D, Allerclear, Bromfed DM, Cheratussin Dac, Clarinex-D, Claritin-D, Codar D, Covan, Entex T, Lodrane D, Mar-cof BP, Mucinex D, Nexafed, Pseudodine C, Rescon Tablets, Semprex-D, Stahist Ad Liquid, Sudafed, Sudafed Sinus & Pain, Sudogest, Triacin-C, Tusnel C, Wal Zyr D, Wal-act, Wal-itin D, Wal-phed, Zephrex-D, Zyrtec-D
Drug Type
Small Molecule
Chemical Formula
C10H15NO
CAS Number
90-82-4
Unique Ingredient Identifier
7CUC9DDI9F
Background

Pseudoephedrine is structurally related to ephedrine but exerts a weaker effect on the sympathetic nervous system. Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseudoephedrine was described in dogs in 1927.

Indication

Pseudoephedrine is a sympathomimetic amine used for its decongestant activity.

Associated Conditions
Allergic Reaction, Allergic Rhinitis (AR), Common Cold, Common Cold Associated With Cough, Cough, Cough caused by Common Cold, Eye allergy, Fever, Flu caused by Influenza, Headache, Irritative cough, Nasal Allergies, Nasal Congestion, Nasal Congestion caused by Common Cold, Pain, Perennial Allergy, Priapism, Respiratory Allergy, Rhinorrhoea, Seasonal Allergic Rhinitis, Seasonal Allergies, Sinus Congestion, Sinusitis, Sneezing, Sore Throat, Symptoms of Acute Bronchitis Accompanied by Coughing, Throat irritation, Upper Respiratory Tract Infection, Upper respiratory tract congestion, Upper respiratory tract signs and symptoms, Cold or flu syndrome, Dry cough, Minor aches and pains, Sinus pain, Watery itchy eyes
Associated Therapies
Airway secretion clearance therapy
Clinical Trials
Related News

Acetylsalicylic Acid Combined With Pseudoephedrine in Common Cold

Phase 3
Completed
Conditions
Common Cold
Interventions
Drug: Placebo
Drug: Acetylsalicylic Acid (Aspirin, BAYE4465)
Drug: Pseudoephedrine
First Posted Date
2009-08-21
Last Posted Date
2014-12-05
Lead Sponsor
Bayer
Target Recruit Count
833
Registration Number
NCT00963443

An Efficacy Study of JNJ-39220675 and Pseudoephedrine in Participants With Allergic Rhinitis

Phase 2
Completed
Conditions
Allergic Rhinitis
Interventions
Other: Placebo
Drug: JNJ-39220675
Drug: Pseudoephedrine
First Posted Date
2008-12-09
Last Posted Date
2013-10-30
Lead Sponsor
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Target Recruit Count
53
Registration Number
NCT00804687

The Effect of Pseudoephedrine on Rhinitis and Sleep

Phase 3
Completed
Conditions
Rhinitis
Sleep
Interventions
Drug: Pseudoephedrine
First Posted Date
2008-06-25
Last Posted Date
2017-10-18
Lead Sponsor
Milton S. Hershey Medical Center
Target Recruit Count
34
Registration Number
NCT00704496
Locations
🇺🇸

Penn State College of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States

Study of the Effect of SCH 900538 on Congestion in Subjects With Seasonal Allergic Rhinitis (Study P05031)(COMPLETED)

Phase 2
Completed
Conditions
Seasonal Allergic Rhinitis
Interventions
Drug: SCH 900538
Drug: Pseudoephedrine
Drug: Placebo Capsules
First Posted Date
2008-05-07
Last Posted Date
2015-11-01
Lead Sponsor
Merck Sharp & Dohme LLC
Target Recruit Count
265
Registration Number
NCT00673062

A Study To Investigate If MRI Scanning Is Effective At Seeing What Hayfever Drugs Do In Nasal Passage.

Completed
Conditions
Seasonal Allergic Rhinitis
Sinusitis
First Posted Date
2007-08-17
Last Posted Date
2013-09-02
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
21
Registration Number
NCT00517946
Locations
🇬🇧

GSK Investigational Site, London, United Kingdom

Study to Assess the Effect of a Combination of Cetirizine With Pseudoephedrine Versus Cetirizine Alone on Symptoms in Patients With Allergic Rhinitis

Not Applicable
Completed
Conditions
Seasonal Allergic Rhinitis
First Posted Date
2006-06-08
Last Posted Date
2010-02-03
Lead Sponsor
Fraunhofer-Institute of Toxicology and Experimental Medicine
Target Recruit Count
51
Registration Number
NCT00334698
Locations
🇩🇪

Fraunhofer-Institute of Toxicology and Experimental Medicine, Hannover, Germany

The Effects of Phenylephrine Compared With Those of Placebo and Pseudoephedrine on Nasal Congestion in Subjects With Seasonal Allergic Rhinitis (SAR)(P04579)

Phase 3
Completed
Conditions
Rhinitis, Allergic, Seasonal
Interventions
Drug: phenylephrine
Drug: pseudoephedrine
Drug: placebo
First Posted Date
2006-01-12
Last Posted Date
2022-02-09
Lead Sponsor
Organon and Co
Target Recruit Count
39
Registration Number
NCT00276016

Treatment of Orthostatic Hypotension in Autonomic Failure

First Posted Date
2005-09-22
Last Posted Date
2017-01-18
Lead Sponsor
Vanderbilt University
Target Recruit Count
389
Registration Number
NCT00223691
Locations
🇺🇸

Vanderbilt University, Nashville, Tennessee, United States

The Autonomic Nervous System and Obesity

Phase 1
Completed
Conditions
HYPERTENSION
OBESITY
SHY-DRAGER SYNDROME
PURE AUTONOMIC FAILURE
Interventions
Drug: Trimethaphan
Drug: Pseudoephedrine
First Posted Date
2005-09-15
Last Posted Date
2018-03-01
Lead Sponsor
Vanderbilt University
Target Recruit Count
128
Registration Number
NCT00179023
Locations
🇺🇸

Vanderbilt University, Nashville, Tennessee, United States

Acupuncture and Herbal Treatment of Chronic HIV Sinusitis

Not Applicable
Completed
Conditions
HIV Infections
Sinusitis
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Immune Enhancement Project
Target Recruit Count
40
Registration Number
NCT00002149
Locations
🇺🇸

Immune Enhancement Project, San Francisco, California, United States

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