Fluorouracil

Generic Name: Fluorouracil

Brand Names: Actikerall, Carac, Efudex, Fluoroplex, Tolak

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃FN_₂O_₂

CAS Number: 51-21-8

Unique Ingredient Identifier: U3P01618RT

Background: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.

Indication: For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.

Associated Conditions: Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis

Associated Therapies: -

Clinical Trials

QUILT-3.045: NANT Merkel Cell Carcinoma (MCC) Vaccine: Combination Immunotherapy in Subjects With MCC Who Have Progressed on or After PD-L1 Therapy

Phase 1

Withdrawn

Conditions: Merkel Cell Carcinoma

Interventions: Biological: Avelumab
Biological: Bevacizumab
Drug: Capecitabine
Drug: Cisplatin
Drug: Cyclophosphamide
Drug: 5-fluorouracil
Drug: Leucovorin
Drug: nab-Paclitaxel
Drug: omega-3-acid ethyl esters
Radiation: Stereotactic Body Radiation Therapy
Biological: ALT-803
Biological: ETBX-051
Biological: ETBX-061
Biological: GI-6301
Biological: haNK

First Posted Date: 2017-05-25

Last Posted Date: 2021-03-19

Lead Sponsor: ImmunityBio, Inc.

Registration Number: NCT03167164

QUILT-3.046: NANT Melanoma Vaccine: Combination Immunotherapy in Subjects With Melanoma Who Have Progressed On or After Chemotherapy and PD-1/PD-L1 Therapy

Phase 1

Withdrawn

Conditions: Melanoma

Interventions: Biological: Avelumab
Biological: Bevacizumab
Drug: Capecitabine
Drug: Cisplatin
Drug: Cyclophosphamide
Drug: 5-fluorouracil
Drug: Leucovorin
Drug: nab-paclitaxel
Biological: Nivolumab
Drug: omega-3-acid ethyl esters
Radiation: Stereotactic Body Radiation Therapy
Biological: ALT-803
Biological: ETBX-011
Biological: ETBX-051
Biological: ETBX-061
Biological: GI-6207
Biological: GI-6301
Biological: haNK

First Posted Date: 2017-05-25

Last Posted Date: 2021-03-19

Lead Sponsor: ImmunityBio, Inc.

Registration Number: NCT03167177

Chemotherapy with or Without Radiation or Surgery in Treating Participants with Oligometastatic Esophageal or Gastric Cancer

Phase 2

Recruiting

Conditions: Gastric Adenocarcinoma
Oligometastasis
Stage IV Esophageal Adenocarcinoma AJCC V7
Stage IV Esophageal Cancer AJCC V7
Stage IV Gastric Cancer AJCC V7

Interventions: Drug: Capecitabine
Drug: Chemotherapy
Procedure: Conventional Surgery
Drug: Fluorouracil
Radiation: Radiation Therapy

First Posted Date: 2017-05-19

Last Posted Date: 2024-10-07

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 100

Registration Number: NCT03161522

Locations: 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States

A Study to Evaluate Efficacy in Subjects With Esophageal Cancer Treated With Nivolumab and Ipilimumab or Nivolumab Combined With Fluorouracil Plus Cisplatin Versus Fluorouracil Plus Cisplatin

Phase 3

Active, not recruiting

Conditions: Various Advanced Cancer

Interventions: Biological: Nivolumab
Drug: Cisplatin
Biological: Ipilimumab
Drug: Fluorouracil

First Posted Date: 2017-05-08

Last Posted Date: 2023-12-04

Lead Sponsor: Bristol-Myers Squibb

Target Recruit Count: 970

Registration Number: NCT03143153

Locations: 🇺🇸
Southern Cancer Center, Inc., Mobile, Alabama, United States
🇺🇸
Arizona Cancer Center, Tucson, Arizona, United States
🇺🇸
Hackensack Meridian Jersey Shore University Medical Center, Neptune, New Jersey, United States

and more 187 locations

FOLFIRI + Panitumumab First-line Treatment in Elderly Patients With Unresectable Metastatic Colorectal Cancer, RAS/BRAF Wild-type and Good Performance Status

Phase 2

Completed

Conditions: Colorectal Neoplasms
Colorectal Carcinoma
Colorectal Cancer Metastatic
Neoplasm Metastasis

Interventions: Drug: Panitumumab
Drug: Irinotecan
Drug: Folinic acid
Drug: 5-FU

First Posted Date: 2017-05-05

Last Posted Date: 2021-06-21

Lead Sponsor: Grupo Espanol Multidisciplinario del Cancer Digestivo

Target Recruit Count: 20

Registration Number: NCT03142516

Locations: 🇪🇸
Hospital Sant Joan Despí-Moises Broggi, Sant Joan Despí, Barcelona, Spain
🇪🇸
ICO L´Hospitalet de Llobregat - Hospital Durán i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain
🇪🇸
Hospital Universitario la Paz, Madrid, Spain

and more 9 locations

QUILT-3.039: NANT Pancreatic Cancer Vaccine: Combination Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy

Phase 1

Terminated

Conditions: Pancreatic Cancer

Interventions: Drug: Cyclophosphamide
Drug: Oxaliplatin
Drug: Capecitabine
Drug: 5-Fluorouracil
Drug: Leucovorin
Drug: nab-paclitaxel
Biological: bevacizumab
Biological: avelumab
Biological: ALT-803
Biological: aNK for Infusion
Biological: ETBX-011
Biological: GI-4000

First Posted Date: 2017-05-02

Last Posted Date: 2024-06-11

Lead Sponsor: ImmunityBio, Inc.

Target Recruit Count: 3

Registration Number: NCT03136406

Locations: 🇺🇸
Chan Soon-Shiong Institute for Medicine, El Segundo, California, United States

NC-6004 With 5-FU and Cetuximab for Treatment of Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

Phase 1

Completed

Conditions: Carcinoma, Squamous Cell of Head and Neck

Interventions: Drug: NC-6004
Drug: Cetuximab
Drug: 5-FU

First Posted Date: 2017-04-12

Last Posted Date: 2019-04-29

Lead Sponsor: NanoCarrier Co., Ltd.

Target Recruit Count: 1

Registration Number: NCT03109158

Locations: 🇧🇬
Complex Oncology Center - Shumen EOOD, Shumen, Bulgaria
🇭🇺
Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz, Nyíregyháza, Hungary
🇺🇸
Cedars Sinai Medical Center, Los Angeles, California, United States

and more 17 locations