Fluorouracil

Generic Name: Fluorouracil

Brand Names: Actikerall, Carac, Efudex, Fluoroplex, Tolak

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃FN_₂O_₂

CAS Number: 51-21-8

Unique Ingredient Identifier: U3P01618RT

Background: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.

Indication: For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.

Associated Conditions: Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis

Associated Therapies: -

Clinical Trials

Study Of Sunitinib In Combination With Cisplatin And 5-Fluorouracil In Patients With Advanced Gastric Cancer

Phase 1

Completed

Conditions: Stomach Neoplasms

Interventions: Drug: 5-fluorouracil
Drug: cisplatin
Drug: sunitinib malate

First Posted Date: 2007-11-09

Last Posted Date: 2011-12-19

Lead Sponsor: Pfizer

Target Recruit Count: 34

Registration Number: NCT00555672

Locations: 🇪🇸
Pfizer Investigational Site, Madrid, Spain

Chemotherapy, Radiation Therapy, and Cetuximab Followed by Surgery, Docetaxel, and Cetuximab in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer

Phase 2

Terminated

Conditions: Esophageal Cancer

Interventions: Drug: 5-Fluorouracil
Drug: Oxaliplatin
Drug: Cetuximab
Drug: Docetaxel
Procedure: Surgery
Radiation: Radiotherapy

First Posted Date: 2007-10-31

Last Posted Date: 2023-07-03

Lead Sponsor: Eastern Cooperative Oncology Group

Target Recruit Count: 22

Registration Number: NCT00551759

Locations: 🇺🇸
Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, Illinois, United States
🇺🇸
Hematology and Oncology Associates, Chicago, Illinois, United States
🇺🇸
Southwest Medical Center, Liberal, Kansas, United States

and more 106 locations

A Study of Bevacizumab in Combination With Capecitabine and Cisplatin as First-line Therapy in Patients With Advanced Gastric Cancer

Phase 3

Completed

Conditions: Adenocarcinoma

Interventions: Drug: Capecitabine
Drug: Bevacizumab
Drug: Cisplatin
Drug: Placebo
Drug: 5-fluorouracil

First Posted Date: 2007-10-24

Last Posted Date: 2017-06-14

Lead Sponsor: Genentech, Inc.

Target Recruit Count: 774

Registration Number: NCT00548548

Locations: 🇺🇸
Cancer Center of Kansas, Wichita, Kansas, United States
🇺🇸
Georgetown University, Washington, D.C., District of Columbia, United States
🇺🇸
USC/Norris Cancer Center, Los Angeles, California, United States

and more 10 locations

Chemotherapy Followed by Surgery, Chemotherapy, and Radiation Therapy in Treating Patients With Locally Advanced Head And Neck Cancer

Phase 2

Active, not recruiting

Conditions: Head and Neck Cancer

Interventions: Drug: cisplatin
Drug: docetaxel
Drug: fluorouracil
Drug: gemcitabine hydrochloride
Drug: leucovorin calcium
Genetic: gene expression analysis
Genetic: protein expression analysis
Other: laboratory biomarker analysis
Procedure: adjuvant therapy
Procedure: biopsy
Procedure: conventional surgery
Procedure: neoadjuvant therapy
Procedure: quality-of-life assessment
Radiation: radiation therapy

First Posted Date: 2007-10-16

Last Posted Date: 2024-02-29

Lead Sponsor: City of Hope Medical Center

Target Recruit Count: 31

Registration Number: NCT00544414

Bevacizumab and Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer

Phase 2

Conditions: Colorectal Cancer

First Posted Date: 2007-10-16

Last Posted Date: 2011-06-27

Lead Sponsor: Hopital Jean Minjoz

Target Recruit Count: 47

Registration Number: NCT00544011

Locations: 🇫🇷
Centre Hospitalier Regional de Besancon - Hopital Jean Minjoz, Besancon, France

Leucovorin, Fluorouracil, Cetuximab, and Oxaliplatin in Treating Patients With Stage IV Colorectal Cancer and Liver Metastases That Cannot Be Removed by Surgery

Phase 2

Completed

Conditions: Colorectal Cancer
Metastatic Cancer

First Posted Date: 2007-10-16

Last Posted Date: 2011-05-17

Lead Sponsor: Gustave Roussy, Cancer Campus, Grand Paris

Target Recruit Count: 45

Registration Number: NCT00544349

Locations: 🇫🇷
Centre Eugene Marquis, Rennes, France
🇫🇷
Centre de Lutte Contre le Cancer Georges-Francois Leclerc, Dijon, France
🇫🇷
Centre Regional Francois Baclesse, Caen, France

and more 4 locations

Fluorouracil, Cisplatin, Cetuximab, and Radiation Therapy in Treating Patients With Esophageal Cancer That Can Be Removed by Surgery

Phase 1

Completed

Conditions: Esophageal Cancer

Interventions: Biological: cetuximab
Drug: cisplatin
Drug: fluorouracil
Procedure: conventional surgery

First Posted Date: 2007-10-16

Last Posted Date: 2016-05-30

Lead Sponsor: Federation Francophone de Cancerologie Digestive

Target Recruit Count: 33

Registration Number: NCT00544362

Locations: 🇫🇷
Centre Hospitalier Regional de Besancon - Hopital Jean Minjoz, Besancon, France
🇫🇷
Centre Hospitalier Regional de Purpan, Toulouse, France
🇫🇷
Centre Alexis Vautrin, Vandoeuvre-les-Nancy, France

and more 10 locations

Radiation Therapy, Chemotherapy, and Cetuximab Followed by Surgery, Chemotherapy, and Cetuximab in Treating Patients With Locally Advanced or Metastatic Rectal Cancer That Can Be Removed by Surgery

Phase 2

Terminated

Conditions: Colorectal Cancer

First Posted Date: 2007-10-08

Last Posted Date: 2020-02-11

Lead Sponsor: UNICANCER

Target Recruit Count: 19

Registration Number: NCT00541112

Locations: 🇫🇷
Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle, Montpellier, France
🇫🇷
Institut Bergonie, Bordeaux, France
🇫🇷
Centre Rene Huguenin, Saint Cloud, France

and more 7 locations