Fluorouracil

Generic Name: Fluorouracil

Brand Names: Actikerall, Carac, Efudex, Fluoroplex, Tolak

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃FN_₂O_₂

CAS Number: 51-21-8

Unique Ingredient Identifier: U3P01618RT

Background: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.

Indication: For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.

Associated Conditions: Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis

Associated Therapies: -

Clinical Trials

Panitumumab Chemoradiotherapy Chemotherapy for Squamous Cancer of the Head and Neck

Phase 1

Completed

Conditions: Squamous Cell Carcinoma of the Head and Neck

Interventions: Drug: Panitumumab
Drug: Carboplatin
Drug: Paclitaxel
Radiation: Intensity Modulated Radiation Therapy
Drug: 5-Fluorouracil
Drug: Docetaxel
Drug: Cisplatin

First Posted Date: 2007-08-08

Last Posted Date: 2017-03-01

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 34

Registration Number: NCT00513383

Locations: 🇺🇸
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

Primary Breast Cancer Occurring Concomitant With Pregnancy

Early Phase 1

Completed

Conditions: Breast Cancer
Pregnancy

Interventions: Drug: 5-Fluorouracil
Drug: Cyclophosphamide
Drug: Doxorubicin

First Posted Date: 2007-08-02

Last Posted Date: 2020-07-10

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 61

Registration Number: NCT00510367

Locations: 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Folfox-B Study for Patients With Colorectal Liver Metastases

Phase 2

Terminated

Conditions: Colorectal Liver Metastases

Interventions: Drug: 5-Fluorouracil
Drug: Bevacizumab
Drug: Leucovorin
Drug: Oxaliplatin

First Posted Date: 2007-07-30

Last Posted Date: 2012-08-01

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 2

Registration Number: NCT00508872

Locations: 🇺🇸
U.T.M.D. Anderson Cancer Center, Houston, Texas, United States

Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, Leucovorin, and Avastin

Phase 1

Completed

Conditions: Liver Cancer
Advanced Solid Tumors

Interventions: Drug: Fluorouracil
Drug: Avastin
Drug: Leucovorin
Drug: Oxaliplatin

First Posted Date: 2007-07-26

Last Posted Date: 2012-07-30

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 63

Registration Number: NCT00507585

Locations: 🇺🇸
U.T.M.D. Anderson Cancer Center, Houston, Texas, United States

Phase I Irinotecan, 5-Fluorouracil and Leucovorin Combination

Phase 1

Completed

Conditions: Metastatic
Colorectal
Adenocarcinoma

Interventions: Drug: ZD6474 (vandetanib) 100mg
Drug: Irinotecan
Drug: 5-Fluorouracil
Drug: ZD6474 (vandetanib) 300mg
Drug: Leucovorin

First Posted Date: 2007-07-25

Last Posted Date: 2016-08-25

Lead Sponsor: Genzyme, a Sanofi Company

Target Recruit Count: 24

Registration Number: NCT00507091

Locations: 🇬🇧
Research Site, Manchester, United Kingdom

Induction Chemotherapy Prior to Radio-immunotherapy in Head and Neck Cancer Stage III/IV - a Methodical Trial

Not Applicable

Completed

Conditions: Head and Neck Cancer

Interventions: Drug: Docetaxel
Drug: Cisplatin
Drug: 5-FU
Radiation: Radiotherapy
Drug: Cetuximab

First Posted Date: 2007-07-17

Last Posted Date: 2024-02-07

Lead Sponsor: Austrian South Oncology Group

Target Recruit Count: 51

Registration Number: NCT00502463

Locations: 🇦🇹
LKH Feldkirch, Dept. of Radiooncology, Feldkirch, Austria
🇦🇹
Medical University of Graz, Dept. of Radiooncology, Graz, Austria
🇦🇹
LKH Leoben Dept. of Hemato-Oncology, Leoben, Austria

and more 2 locations