Fluorouracil

Generic Name: Fluorouracil

Brand Names: Actikerall, Carac, Efudex, Fluoroplex, Tolak

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃FN_₂O_₂

CAS Number: 51-21-8

Unique Ingredient Identifier: U3P01618RT

Background: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.

Indication: For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.

Associated Conditions: Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis

Associated Therapies: -

Clinical Trials

Fluorouracil With or Without Mitomycin in Treating Patients With Peritoneal Cancer

Phase 2

Conditions: Carcinoma of the Appendix
Colorectal Cancer
Primary Peritoneal Cavity Cancer

First Posted Date: 2004-05-04

Last Posted Date: 2011-04-26

Lead Sponsor: Gustave Roussy, Cancer Campus, Grand Paris

Registration Number: NCT00006112

Locations: 🇫🇷
Institut Gustave Roussy, Villejuif, France

Nitrocamptothecin or Fluorouracil in Treating Patients With Recurrent or Refractory Pancreatic Cancer

Phase 3

Conditions: Pancreatic Cancer

First Posted Date: 2004-05-03

Last Posted Date: 2013-12-04

Lead Sponsor: Astex Pharmaceuticals, Inc.

Registration Number: NCT00005871

Locations: 🇺🇸
SuperGen, Incorporated, San Ramon, California, United States

Standard Chemotherapy Compared With High-Dose Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Women With Advanced or Inflammatory Breast Cancer

Phase 3

Conditions: Breast Cancer

First Posted Date: 2004-05-03

Last Posted Date: 2013-11-06

Lead Sponsor: Scottish Cancer Therapy Network

Target Recruit Count: 300

Registration Number: NCT00003680

Locations: 🇬🇧
C.R.C. Beatson Laboratories, Glasgow, Scotland, United Kingdom

Fluorouracil in Treating Patients With Recurrent or Metastatic Bladder Cancer

Phase 2

Completed

Conditions: Bladder Cancer
Transitional Cell Cancer of the Renal Pelvis and Ureter
Urethral Cancer

First Posted Date: 2004-04-30

Last Posted Date: 2013-12-04

Lead Sponsor: Medical Research Council

Target Recruit Count: 45

Registration Number: NCT00003175

Locations: 🇧🇷
Porto Alegre Hospital, Porto Alegre, Rio Grande do Sul, Brazil
🇨🇦
Cancer Care Ontario-London Regional Cancer Centre, London, Ontario, Canada
🇨🇦
Princess Margaret Hospital, Toronto, Ontario, Canada

and more 59 locations

ONYX-015 With Cisplatin and Fluorouracil in Treating Patients With Advanced Head and Neck Cancer

Phase 1

Withdrawn

Conditions: Lip and Oral Cavity Cancer
Head and Neck Cancer
Oropharyngeal Cancer

First Posted Date: 2004-04-29

Last Posted Date: 2013-07-10

Lead Sponsor: National Cancer Institute (NCI)

Registration Number: NCT00006106

Locations: 🇺🇸
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
🇺🇸
Dana-Farber Cancer Institute, Boston, Massachusetts, United States