Fluorouracil
- Generic Name
- Fluorouracil
- Brand Names
- Actikerall, Carac, Efudex, Fluoroplex, Tolak
- Drug Type
- Small Molecule
- Chemical Formula
- C4H3FN2O2
- CAS Number
- 51-21-8
- Unique Ingredient Identifier
- U3P01618RT
- Background
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
- Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
- Associated Conditions
- Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis
- Associated Therapies
- -
S9700 Combination Chemotherapy in Treating Patients With Stage II or Stage III Pancreatic Cancer
- Conditions
- Interventions
- First Posted Date
- 2004-04-22
- Last Posted Date
- 2013-01-03
- Lead Sponsor
- SWOG Cancer Research Network
- Target Recruit Count
- 54
- Registration Number
- NCT00003018
- Locations
- 🇺🇸
MBCCOP - University of South Alabama, Mobile, Alabama, United States
🇺🇸Loyola University Medical Center, Maywood, Illinois, United States
🇺🇸USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States
Leucovorin and Fluorouracil With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer
- Conditions
- First Posted Date
- 2004-04-19
- Last Posted Date
- 2012-09-11
- Lead Sponsor
- Pfizer
- Registration Number
- NCT00004252
- Locations
- 🇺🇸
Tower Hematology Oncology Medical Group, Los Angeles, California, United States
🇺🇸Raleigh Hematology/Oncology Associates - Wake Practice, Raleigh, North Carolina, United States
🇺🇸APN-IMPATH Research Corporation, Fort Lee, New Jersey, United States
Radiation Therapy With or Without Chemotherapy After Surgery in Treating Patients With Stage IB or Stage IIA Cervical Cancer
- Conditions
- First Posted Date
- 2004-04-14
- Last Posted Date
- 2012-07-11
- Target Recruit Count
- 700
- Registration Number
- NCT00003209
- Locations
- 🇬🇧
Derbyshire Royal Infirmary, Derby, England, United Kingdom
🇬🇧Beatson Oncology Centre, Glasgow, Scotland, United Kingdom
Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer
- Conditions
- Interventions
- First Posted Date
- 2004-04-14
- Last Posted Date
- 2016-07-06
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 44
- Registration Number
- NCT00003834
- Locations
- 🇺🇸
CCOP - Carle Cancer Center, Urbana, Illinois, United States
🇺🇸CCOP - Duluth, Duluth, Minnesota, United States
🇺🇸CentraCare Clinic, Saint Cloud, Minnesota, United States
Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer
- Conditions
- First Posted Date
- 2004-04-13
- Last Posted Date
- 2013-12-19
- Lead Sponsor
- Jonsson Comprehensive Cancer Center
- Registration Number
- NCT00021281
- Locations
- 🇺🇸
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States
Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Chemotherapy Alone in Treating Women With Stage IV Breast Cancer
- Conditions
- First Posted Date
- 2004-04-13
- Last Posted Date
- 2014-01-06
- Lead Sponsor
- Herbert Irving Comprehensive Cancer Center
- Registration Number
- NCT00012311
- Locations
- 🇺🇸
Herbert Irving Comprehensive Cancer Center, New York, New York, United States
Radiation Therapy and Chemotherapy Followed by Surgery and Combination Chemotherapy in Treating Patients With Rectal Cancer
- Conditions
- Interventions
- First Posted Date
- 2004-04-13
- Last Posted Date
- 2020-06-05
- Lead Sponsor
- Fox Chase Cancer Center
- Target Recruit Count
- 23
- Registration Number
- NCT00021398
- Locations
- 🇺🇸
Community Medical Center, Toms River, New Jersey, United States
🇺🇸Reading Hospital and Medical Center, Reading, Pennsylvania, United States
🇺🇸Kimball Medical Center, Lakewood, New Jersey, United States
Combination Chemotherapy Plus Interferon Alfa Followed by Filgrastim in Treating Patients With Gastrointestinal Tract Cancer
- First Posted Date
- 2004-04-13
- Last Posted Date
- 2018-09-14
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT00019474
- Locations
- 🇺🇸
Albert Einstein Comprehensive Cancer Center, Bronx, New York, United States
Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients With Metastatic Colorectal Cancer
- Conditions
- First Posted Date
- 2004-04-12
- Last Posted Date
- 2012-09-24
- Target Recruit Count
- 430
- Registration Number
- NCT00004885
- Locations
- 🇪🇬
National Cancer Institute of Egypt, Cairo, Egypt
🇩🇪St. Johannes Hospital - Medical Klinik II, Duisburg, Germany
🇩🇪Universitaetsklinik und Strahlenklinik - Essen, Essen, Germany
Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
- Conditions
- First Posted Date
- 2004-04-12
- Last Posted Date
- 2011-03-28
- Lead Sponsor
- NYU Langone Health
- Registration Number
- NCT00004102
- Locations
- 🇺🇸
NYU School of Medicine's Kaplan Comprehensive Cancer Center, New York, New York, United States
Drug Development Updates
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