Fluorouracil

Generic Name: Fluorouracil

Brand Names: Actikerall, Carac, Efudex, Fluoroplex, Tolak

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃FN_₂O_₂

CAS Number: 51-21-8

Unique Ingredient Identifier: U3P01618RT

Background: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.

Indication: For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.

Associated Conditions: Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis

Associated Therapies: -

Clinical Trials

Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer

Phase 2

Completed

Conditions: Colorectal Cancer

First Posted Date: 2004-04-09

Last Posted Date: 2013-06-26

Lead Sponsor: Grupo Oncologico Cooperativo del Sur

Registration Number: NCT00003446

Locations: 🇦🇷
Grupo Oncologico Cooperativo del Sur, Bahia Blanca, Buenos Aires, Argentina

Radiation Therapy and Chemotherapy Following Surgery in Treating Patients With Stage II or Stage III Bladder Cancer

Phase 2

Terminated

Conditions: Bladder Cancer

First Posted Date: 2004-04-09

Last Posted Date: 2012-03-06

Lead Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Target Recruit Count: 43

Registration Number: NCT00003642

Locations: 🇫🇷
Institut Bergonie, Bordeaux, France
🇫🇷
CHR de Grenoble - La Tronche, Grenoble, France
🇳🇱
Dr. Bernard Verbeeten Instituut, Tilburg, Netherlands

Irinotecan, Fluorouracil, Leucovorin, and Oxaliplatin as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

Phase 2

Completed

Conditions: Colorectal Cancer

Interventions: Drug: fluorouracil
Drug: irinotecan hydrochloride
Drug: leucovorin calcium
Drug: oxaliplatin

First Posted Date: 2004-04-08

Last Posted Date: 2016-12-07

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 14

Registration Number: NCT00080951

Alvocidib, Oxaliplatin, Fluorouracil, and Leucovorin Calcium in Treating Patients With Advanced Solid Tumors

Phase 1

Completed

Conditions: Unspecified Adult Solid Tumor, Protocol Specific

Interventions: Drug: alvocidib
Drug: fluorouracil
Drug: oxaliplatin
Drug: leucovorin calcium

First Posted Date: 2004-04-08

Last Posted Date: 2013-12-16

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 46

Registration Number: NCT00080990

Locations: 🇺🇸
Memorial Sloan-Kettering Cancer Center, New York, New York, United States

Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy in Treating Patients Who Are Undergoing Surgical Resection for Locally Advanced Rectal Cancer

Phase 2

Completed

Conditions: Colorectal Cancer

Interventions: Radiation: Radiation Therapy
Drug: Capecitabine 1200 mg/m^2/day
Drug: Capecitabine 1650 mg/m^2/day
Drug: Oxaliplatin
Drug: Irinotecan
Procedure: Surgery
Drug: Folinic Acid
Drug: Fluorouracil

First Posted Date: 2004-04-08

Last Posted Date: 2020-02-27

Lead Sponsor: Radiation Therapy Oncology Group

Target Recruit Count: 146

Registration Number: NCT00081289

Locations: 🇺🇸
Baptist-South Miami Regional Cancer Program, Miami, Florida, United States
🇺🇸
University of California Davis Cancer Center, Sacramento, California, United States
🇺🇸
Ingalls Cancer Care Center at Ingalls Memorial Hospital, Harvey, Illinois, United States

and more 2 locations

Perioperative Chemotherapy in Treating Patients With Colon Cancer That Can Be Surgically Removed

Phase 3

Terminated

Conditions: Colorectal Cancer

Interventions: Drug: fluorouracil
Drug: leucovorin calcium

First Posted Date: 2004-04-06

Last Posted Date: 2023-06-28

Lead Sponsor: ECOG-ACRIN Cancer Research Group

Target Recruit Count: 859

Registration Number: NCT00002525

Locations: 🇺🇸
Loyola University Medical Center, Maywood, Illinois, United States

Combination Chemotherapy Following Surgery in Treating Women With Early Stage Breast Cancer

Phase 3

Completed

Conditions: Breast Cancer

First Posted Date: 2004-04-06

Last Posted Date: 2013-11-06

Lead Sponsor: Scottish Cancer Therapy Network

Target Recruit Count: 1000

Registration Number: NCT00003012

Locations: 🇬🇧
Aberdeen Royal Infirmary, Aberdeen, Scotland, United Kingdom
🇬🇧
Royal Alexandra Hospital, Paisley, Scotland, United Kingdom
🇬🇧
Western General Hospital, Edinburgh, Scotland, United Kingdom

and more 7 locations

Radiation Therapy and Combination Chemotherapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer

Phase 2

Completed

Conditions: Squamous Neck Carcinoma of the Head and Neck Cancer (SCCHN)

Interventions: Drug: Tirapazamine
Drug: Cisplatin
Drug: 5-fluorouracil
Radiation: Radiotherapy (RT)

First Posted Date: 2004-04-06

Last Posted Date: 2014-06-20

Lead Sponsor: Stanford University

Target Recruit Count: 63

Registration Number: NCT00002774

Locations: 🇺🇸
Veterans Affairs Medical Center - Palo Alto, Palo Alto, California, United States
🇺🇸
Stanford University Medical Center, Stanford, California, United States