Fluorouracil
- Generic Name
- Fluorouracil
- Brand Names
- Actikerall, Carac, Efudex, Fluoroplex, Tolak
- Drug Type
- Small Molecule
- Chemical Formula
- C4H3FN2O2
- CAS Number
- 51-21-8
- Unique Ingredient Identifier
- U3P01618RT
- Background
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
- Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
- Associated Conditions
- Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis
- Associated Therapies
- -
Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Head and Neck Cancer
- Conditions
- First Posted Date
- 2004-06-09
- Last Posted Date
- 2013-08-02
- Lead Sponsor
- Cancer Research UK
- Registration Number
- NCT00002476
- Locations
- 🇬🇧
Derriford Hospital, Plymouth, England, United Kingdom
🇬🇧Southend General Hospital, Westcliff-On-Sea, England, United Kingdom
🇬🇧Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom
Eniluracil, Fluorouracil, and Oxaliplatin in Treating Patients With Advanced Colorectal Cancer
- Conditions
- First Posted Date
- 2004-06-08
- Last Posted Date
- 2011-03-28
- Lead Sponsor
- NYU Langone Health
- Registration Number
- NCT00005050
- Locations
- 🇺🇸
Kaplan Cancer Center, New York, New York, United States
Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver
- Conditions
- First Posted Date
- 2004-05-21
- Last Posted Date
- 2013-12-19
- Lead Sponsor
- Medical Research Council
- Target Recruit Count
- 312
- Registration Number
- NCT00002692
- Locations
- 🇬🇧
University Birmingham, Birmingham, England, United Kingdom
Combination Chemotherapy in Treating Women With Stage II or Stage III Breast Cancer
- Conditions
- First Posted Date
- 2004-05-20
- Last Posted Date
- 2013-12-18
- Target Recruit Count
- 1000
- Registration Number
- NCT00005581
- Locations
- 🇮🇹
Ospedale S. Paolo, Savona, Italy
🇮🇹Ospedale Oncologico A. Businco, Cagliari, Italy
🇮🇹I.R.C.C.S. Policlinico San Matteo, Pavia, Italy
Chemotherapy in Treating Patients With Locally Advanced or Metastatic Cancer of the Pancreas or Bile Duct
- Conditions
- Locations
- 🇫🇷
Polyclinique De Courlancy, Reims, France
🇫🇷Centre Saint-Yves, Vannes, France
🇫🇷Institut Bergonie, Bordeaux, France
Surgery With or Without Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Esophagus
- Conditions
- Interventions
- First Posted Date
- 2004-05-19
- Last Posted Date
- 2016-07-04
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 56
- Registration Number
- NCT00003118
- Locations
- 🇺🇸
University of Illinois at Chicago Health Sciences Center, Chicago, Illinois, United States
🇺🇸University of Chicago Cancer Research Center, Chicago, Illinois, United States
🇺🇸Marlene & Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, United States
Fluorouracil and Low-Dose Suramin as Chemosensitization in Treating Patients With Metastatic Renal Cell (Kidney) Cancer
- Conditions
- Interventions
- First Posted Date
- 2004-05-17
- Last Posted Date
- 2015-05-25
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 36
- Registration Number
- NCT00083109
- Locations
- 🇺🇸
Cleveland Clinic Foundation, Cleveland, Ohio, United States
Radiation Therapy Plus Chemotherapy Before Surgery With or Without Chemotherapy After Surgery in Treating Patients With Rectal Cancer
- Conditions
- First Posted Date
- 2004-05-13
- Last Posted Date
- 2013-09-20
- Lead Sponsor
- European Institute of Oncology
- Target Recruit Count
- 774
- Registration Number
- NCT00002896
- Locations
- 🇮🇹
Ospedale St. Santa Chiara, Pisa, Italy
Palliative Chemotherapy in Treating Patients With Advanced Colorectal Cancer
- Conditions
- First Posted Date
- 2004-05-13
- Last Posted Date
- 2013-12-19
- Lead Sponsor
- Medical Research Council
- Target Recruit Count
- 900
- Registration Number
- NCT00002893
- Locations
- 🇬🇧
Velindre Hospital, Cardiff, Wales, United Kingdom
High Dose Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Standard Therapy in Treating Women With Locally Recurrent or Metastatic Breast Cancer
- Conditions
- First Posted Date
- 2004-05-12
- Last Posted Date
- 2014-12-16
- Lead Sponsor
- UNICANCER
- Target Recruit Count
- 180
- Registration Number
- NCT00002870
- Locations
- 🇫🇷
Centre Paul Papin, Angers, France
🇫🇷Clinique Saint Vincent, Besancon, France
🇫🇷C.H. Bourg En Bresse, Bourg En Bresse, France
Drug Development Updates
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