Methimazole
- Generic Name
- Methimazole
- Brand Names
- Tapazole
- Drug Type
- Small Molecule
- Chemical Formula
- C4H6N2S
- CAS Number
- 60-56-0
- Unique Ingredient Identifier
- 554Z48XN5E
- Background
Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones. It was first introduced as an antithyroid agent in 1949 and is now commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive options such as surgery or radioactive iodine therapy are inappropriate.
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- Indication
In the United States, methimazole is indicated for the treatment of hyperthyroidism in patients with Graves' disease or toxic multinodular goiter for whom thyroidectomy or radioactive iodine therapy are not appropriate treatment options. Methimazole is also indicated for the amelioration of hyperthyroid symptoms in preparation for thyroidectomy or radioactiv...
- Associated Conditions
- Graves' Disease, Hyperthyroidism, Toxic multinodular goiter
- Associated Therapies
- -
Evaluation of Optimal Time of Methimazole Discontinuation Before Radio-iodine Therapy in Hyperthyroid Grave's Patients
- First Posted Date
- 2012-03-22
- Last Posted Date
- 2012-03-22
- Lead Sponsor
- Mashhad University of Medical Sciences
- Target Recruit Count
- 150
- Registration Number
- NCT01560299
- Locations
- 🇮🇷
Mashad University of Medical Sciences, Mashad, Khorasan Razavi, Iran, Islamic Republic of
Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study)
- Conditions
- Interventions
- First Posted Date
- 2011-10-25
- Last Posted Date
- 2016-02-24
- Lead Sponsor
- Mikael Lantz
- Target Recruit Count
- 65
- Registration Number
- NCT01458600
- Locations
- 🇸🇪
Departmenty of Endocrinology, Skane University Hospital, Malmö, Sweden
🇸🇪Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden
🇸🇪Department of Internal Medicine, section of Endocrinology, Sodersjukhuset, Stockholm, Sweden
Block-replacement Therapy During Radioiodine Therapy
- Conditions
- Interventions
- First Posted Date
- 2005-09-08
- Last Posted Date
- 2013-12-04
- Lead Sponsor
- Steen Bonnema
- Target Recruit Count
- 100
- Registration Number
- NCT00150124
- Locations
- 🇩🇰
Department of Endocrinology, Odense University Hospital, Odense, Funen, Denmark
Rituximab in the Treatment of Graves' Disease
- Conditions
- First Posted Date
- 2005-09-08
- Last Posted Date
- 2006-10-06
- Lead Sponsor
- Odense University Hospital
- Target Recruit Count
- 20
- Registration Number
- NCT00150111
- Locations
- 🇩🇰
Department of Endocrinology, Odense University Hospital, Odense, Funen, Denmark
🇩🇰Department of Hematology, Odense University Hospital, Odense, Denmark
Antithyroid Drugs During Radioiodine Therapy
- Conditions
- First Posted Date
- 2005-09-08
- Last Posted Date
- 2006-02-03
- Lead Sponsor
- Odense University Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT00150137
- Locations
- 🇩🇰
Department of Endocrinology, Odense University Hospital, Odense, Funen, Denmark
Methimazole to Treat Polymyositis and Dermatomyositis
- Conditions
- First Posted Date
- 2002-12-10
- Last Posted Date
- 2008-03-04
- Target Recruit Count
- 20
- Registration Number
- NCT00001421
- Locations
- 🇺🇸
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, Maryland, United States
Drug Development Updates
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