Nitrofurantoin
- Generic Name
- Nitrofurantoin
- Brand Names
- Furadantin, Macrobid, Macrodantin
- Drug Type
- Small Molecule
- Chemical Formula
- C8H6N4O5
- CAS Number
- 67-20-9
- Unique Ingredient Identifier
- 927AH8112L
- Background
Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections. Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. This drug is more resistant to the development of bacterial resistance because it acts on many targets at once. Nitrofurantoin is a second line treatment to trimethoprim/sulfamethoxazole.
Nitrofurantoin was granted FDA approval on 6 February 1953.
- Indication
Nitrofurantoin is indicated to treat acute uncomplicated urinary tract infections.
- Associated Conditions
- Acute Cystitis, Urinary Tract Infection
Cranberry Tablets Versus Nitrofurantoin Prophylaxis for Urinary Tract Infection Prevention After Urogynecologic Surgery
- Conditions
- Urinary Tract InfectionsPelvic Organ ProlapseUrinary Incontinence
- Interventions
- First Posted Date
- 2018-05-14
- Last Posted Date
- 2023-08-28
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 142
- Registration Number
- NCT03522961
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Oral Omadacycline vs. Oral Nitrofurantoin for the Treatment of Cystitis
- Conditions
- CystitisUncomplicated Urinary Tract Infection
- Interventions
- First Posted Date
- 2018-02-07
- Last Posted Date
- 2020-06-09
- Lead Sponsor
- Paratek Pharmaceuticals Inc
- Target Recruit Count
- 225
- Registration Number
- NCT03425396
- Locations
- 🇺🇸
Site 101, La Mesa, California, United States
🇺🇸Site 102, DeLand, Florida, United States
🇺🇸Site 114, Aventura, Florida, United States
INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI
- First Posted Date
- 2017-10-03
- Last Posted Date
- 2019-06-06
- Lead Sponsor
- Mayo Clinic
- Registration Number
- NCT03299387
Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery
- Conditions
- Catheter-Associated Urinary Tract Infection
- Interventions
- Drug: Placebo Oral Tablet
- First Posted Date
- 2017-09-19
- Last Posted Date
- 2022-08-09
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 164
- Registration Number
- NCT03287089
- Locations
- 🇺🇸
Atrium Health, Charlotte, North Carolina, United States
Treatment of Asymptomatic Bacteriuria in Pregnancy
- Conditions
- Bacteriuria (Asymptomatic) in Pregnancy
- Interventions
- First Posted Date
- 2016-09-22
- Last Posted Date
- 2018-04-18
- Lead Sponsor
- Saint Joseph Mercy Health System
- Target Recruit Count
- 13
- Registration Number
- NCT02911662
- Locations
- 🇺🇸
St. Joseph Mercy Hospital, Ypsilanti, Michigan, United States
Endourology Disease Group Excellence (EDGE) Consortium: Antibiotics (Abx) for Percutaneous Nephrolithotomy (PCNL) Part 2
- Conditions
- SepsisUrinary Tract Infection (UTI)Nephrolithiasis
- Interventions
- Drug: Gentamicin, 5mg/kgDrug: Gentamicin, 80 mg, 7dDrug: Gentamicin, 80 mg, 48hr
- First Posted Date
- 2016-07-12
- Last Posted Date
- 2025-03-06
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 330
- Registration Number
- NCT02829060
- Locations
- 🇺🇸
University of California San Diego, San Diego, California, United States
The Preventive Infection Role of One Week Antibiotics Before Minimally Invasive Upper Tract Lithotomy
- Conditions
- Complication of Surgical Procedure
- Interventions
- First Posted Date
- 2016-06-03
- Last Posted Date
- 2019-10-01
- Target Recruit Count
- 150
- Registration Number
- NCT02789579
- Locations
- 🇨🇳
Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine.Kongjiang Road 1665,, Shanghai, Shanghai, China
Nitrofurantoin Prophylaxis During Catheter-managed Acute Urinary Retention After Pelvic Reconstructive Surgery
- First Posted Date
- 2016-04-04
- Last Posted Date
- 2019-05-29
- Lead Sponsor
- Halina M Zyczynski, MD
- Target Recruit Count
- 154
- Registration Number
- NCT02727322
- Locations
- 🇺🇸
Georgetown/MedStar Hospital Center, Washington, District of Columbia, United States
🇺🇸Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States
A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])
- Conditions
- NephrolithiasisUrinary Tract Infections
- Interventions
- First Posted Date
- 2015-03-10
- Last Posted Date
- 2019-08-22
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 86
- Registration Number
- NCT02384200
- Locations
- 🇺🇸
Mayo Clinic in Arizona, Phoenix, Arizona, United States
🇺🇸UCSD Medical Center, San Diego, California, United States
🇺🇸The Ohio State University Wexner Medical Center, Columbus, Ohio, United States
Struvite Stones Antibiotic Study
- Conditions
- Kidney Stones
- Interventions
- First Posted Date
- 2015-03-02
- Last Posted Date
- 2022-05-17
- Lead Sponsor
- University of British Columbia
- Target Recruit Count
- 28
- Registration Number
- NCT02375295
- Locations
- 🇺🇸
Cleveland Clinic Foundation, Cleveland, Ohio, United States
🇺🇸Mayo Clinic - Scottsdale/Phoenix, AZ, Scottsdale, Arizona, United States
🇺🇸University California San Diego, San Diego, California, United States
Drug Development Updates
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