Nitrofurantoin

Generic Name: Nitrofurantoin

Brand Names: Furadantin, Macrobid, Macrodantin

Drug Type: Small Molecule

Chemical Formula: C_₈H_₆N_₄O_₅

CAS Number: 67-20-9

Unique Ingredient Identifier: 927AH8112L

Background: Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections. Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. This drug is more resistant to the development of bacterial resistance because it acts on many targets at once. Nitrofurantoin is a second line treatment to trimethoprim/sulfamethoxazole.

Nitrofurantoin was granted FDA approval on 6 February 1953.

Indication: Nitrofurantoin is indicated to treat acute uncomplicated urinary tract infections.

Associated Conditions: Acute Cystitis, Urinary Tract Infection

Clinical Trials

An Open Clinical Trial of the Safety and Efficacy of the Drug Fluorothiazinone, 300 Mg Tablets with the Participation of Adult Patients with Chronic Bacterial Cystitis"

Phase 3

Not yet recruiting

Conditions: P. Aeruginosa
Baumannii
Klebsiella Pneumonia
E.coli Infections
Enterococcus Faecalis Infection
Chronic Bacterial Cystitis

Interventions: Drug: Fluorothiazinone, tablets 300 mg
Drug: Nitrofurantoin 100 MG

First Posted Date: 2025-02-07

Last Posted Date: 2025-02-07

Lead Sponsor: Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation

Target Recruit Count: 280

Registration Number: NCT06815549

Asymptomatic Bacteriuria in Pregnancy in Low- and Middle-IncomE Countries

Phase 3

Not yet recruiting

Conditions: Preterm Birth
Small for Gestational Age (SGA)
Stillbirth
Bacteriuria (asymptomatic) in Pregnancy

Interventions: Drug: Oral nitrofurantoin monohydrate/macrocrystals
Other: Placebo

First Posted Date: 2024-12-09

Last Posted Date: 2024-12-18

Lead Sponsor: NICHD Global Network for Women's and Children's Health

Target Recruit Count: 1134

Registration Number: NCT06723392

Locations: 🇧🇩
Icddr,B, Dhaka, Bangladesh
🇨🇩
Kinshasa School of Public Health, Kinshasa, DRC, Congo, The Democratic Republic of the
🇬🇹
Institue for Nutrition of Central America and Panama (INCAP), Guatemala City, Guatemala

and more 4 locations

Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis

Phase 4

Recruiting

Conditions: Cystectomy
Bladder Cancer Requiring Cystectomy
Postoperative Infections
Antibiotic Prophylaxis
Ileal Conduit

Interventions: Drug: Pivmecillinam
Drug: Amoxicillin clavulanic acid
Drug: Amoxicillin
Drug: Cefuroxime
Drug: Ciprofloxacin
Drug: Linezolid
Drug: Nitrofurantoin
Drug: Trimethoprim
Drug: Sulfamethoxazole trimethoprim
Drug: Fluconazole

First Posted Date: 2024-11-29

Last Posted Date: 2025-01-09

Lead Sponsor: Rigshospitalet, Denmark

Target Recruit Count: 248

Registration Number: NCT06709196

Locations: 🇩🇰
Department of Urology, Aalborg University Hospital, Aalborg, Denmark
🇩🇰
Department of Urology, Aarhus University Hospital, Aarhus, Denmark
🇩🇰
Department of Urology, Rigshospitalet, Copenhagen, Denmark

and more 2 locations

COMPARISON OF NITROFURANTOIN WITH FOSFOMYCIN in TREATING CYSTITIS IN WOMEN

Phase 4

Not yet recruiting

Conditions: Urinary Tract Infections

Interventions: Drug: Nitrofurantoin 100 MG
Drug: Fosfomycin

First Posted Date: 2024-07-24

Last Posted Date: 2024-07-24

Lead Sponsor: Shalamar Institute of Health Sciences

Target Recruit Count: 392

Registration Number: NCT06518291

Bladder Botox UTI Antibiotic Prophylaxis

Phase 4

Recruiting

Conditions: Overactive Bladder
Bladder Pain Syndrome

Interventions: Drug: Nitrofurantoin 100 MG

First Posted Date: 2024-04-29

Last Posted Date: 2025-02-19

Lead Sponsor: Walter Reed National Military Medical Center

Target Recruit Count: 100

Registration Number: NCT06387329

Locations: 🇺🇸
Walter Reed National Military Medical Center, Bethesda, Maryland, United States

Intravesical Gentamicin to Prevent Recurrent UTI

Phase 4

Recruiting

Conditions: Recurrent Uti

Interventions: Drug: Nitrofurantoin
Drug: Gentamicin

First Posted Date: 2024-03-27

Last Posted Date: 2025-05-08

Lead Sponsor: Women and Infants Hospital of Rhode Island

Target Recruit Count: 30

Registration Number: NCT06332781

Locations: 🇺🇸
Women & Infants Hospital, Providence, Rhode Island, United States

Gag Therapy for Recurrent Urinary Tract Infection Assessing Comparability to International Nitrofurantoin Gold Standard Study

Phase 4

Recruiting

Conditions: Recurrent Urinary Tract Infection

Interventions: Device: Ialuril 50ml Prefill
Drug: Nitrofurantoin

First Posted Date: 2022-12-15

Last Posted Date: 2024-11-18

Lead Sponsor: Radboud University Medical Center

Target Recruit Count: 100

Registration Number: NCT05652374

Locations: 🇳🇱
Rijnstate ziekenhuis, Arnhem, Netherlands
🇳🇱
Canisius wilhelmina ziekenhuis, Nijmegen, Netherlands
🇳🇱
Radboudumc, Nijmegen, Gelderland, Netherlands