Carvedilol
- Generic Name
- Carvedilol
- Brand Names
- Coreg
- Drug Type
- Small Molecule
- Chemical Formula
- C24H26N2O4
- CAS Number
- 72956-09-3
- Unique Ingredient Identifier
- 0K47UL67F2
- Background
Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. It is currently used to treat heart failure, left ventricular dysfunction, and hypertension. The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs ...
- Indication
Carvedilol is indicated to treat mild to severe heart failure, left ventricular dysfunction after myocardial infarction with ventricular ejection fraction ≤40%, or hypertension.
- Associated Conditions
- Atrial Fibrillation, Chronic Stable Angina Pectoris, Hypertension, LVEF ≤40% Left ventricular dysfunction, NYHA Class I or II heart failure, Chronic heart failure with reduced ejection fraction (NYHA Class III), Chronic heart failure with reduced ejection fraction (NYHA Class IV)
- Associated Therapies
- -
A Comparison of the Effect of Carvedilol and Metoprolol on Airways Tone in Patients With Heart Failure
- Conditions
- Interventions
- First Posted Date
- 2006-10-06
- Last Posted Date
- 2015-06-24
- Lead Sponsor
- The Alfred
- Registration Number
- NCT00384566
- Locations
- 🇦🇺
Alfred Hospital, Melbourne, Victoria, Australia
Therapy With Verapamil or Carvedilol in Chronic Heart Failure
- Conditions
- First Posted Date
- 2006-09-11
- Last Posted Date
- 2006-09-11
- Lead Sponsor
- Medical University of Silesia
- Target Recruit Count
- 100
- Registration Number
- NCT00374465
- Locations
- 🇵🇱
Silesian Centre for Heart Disease, 3rd Department of Cardiology, Zabrze, Szpitalna 2 st., Poland
RATe Control in Atrial Fibrillation
- Conditions
- Interventions
- First Posted Date
- 2006-04-12
- Last Posted Date
- 2014-05-13
- Lead Sponsor
- Asker & Baerum Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT00313157
- Locations
- 🇳🇴
Vestre Viken Hospital Trust, Baerum Hospital, Rud, Akershus, Norway
Drug Compliance and Quality of Life in Patients With Heart Failure Dosed With Either Once-daily or Twice-daily Coreg
- Conditions
- First Posted Date
- 2006-01-09
- Last Posted Date
- 2013-02-18
- Lead Sponsor
- Cardiovascular Clinical Studies
- Target Recruit Count
- 400
- Registration Number
- NCT00272805
- Locations
- 🇺🇸
Idaho Cardiology Associates, Boise, Idaho, United States
🇺🇸St. Francis Hospital and Medical Center, Hartford, Connecticut, United States
🇺🇸Charlotte Heart Group Research Center, Port Charlotte, Florida, United States
Study to Evaluate the Safety of Twice Daily Oral Carvedilol
- Conditions
- First Posted Date
- 2005-08-11
- Last Posted Date
- 2008-12-25
- Lead Sponsor
- Shaddy, Robert, M.D.
- Target Recruit Count
- 75
- Registration Number
- NCT00129363
- Locations
- 🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
🇺🇸Washington University, St. Louis, Missouri, United States
Vascular Effects of Carvedilol Versus Metoprolol in Hypertensive Patients With Type 2 Diabetes
- Conditions
- Interventions
- First Posted Date
- 2005-07-25
- Last Posted Date
- 2014-11-18
- Lead Sponsor
- St. Paul Heart Clinic
- Target Recruit Count
- 36
- Registration Number
- NCT00123604
- Locations
- 🇺🇸
St. Paul Heart Clinic, St. Paul, Minnesota, United States
Effect Of Carvedilol Versus Metoprolol On Glycemic Control In Patients With Type II Diabetes And Hypertension
- Conditions
- First Posted Date
- 2003-05-16
- Last Posted Date
- 2015-04-14
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 501
- Registration Number
- NCT00060931
- Locations
- 🇺🇸
GSK Investigational Site, Springfield, Virginia, United States
Glycemic Control Of Carvedilol Versus Metoprolol In Patients With Type II Diabetes Mellitus And Hypertension
- Conditions
- First Posted Date
- 2003-05-16
- Last Posted Date
- 2015-04-15
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 1210
- Registration Number
- NCT00060918
- Locations
- 🇺🇸
GSK Investigational Site, Milwaukee, Wisconsin, United States
Safety and Efficacy Study of Carvedilol to Treat Children With Congestive Heart Failure
- First Posted Date
- 2003-01-23
- Last Posted Date
- 2008-12-25
- Lead Sponsor
- Shaddy, Robert, M.D.
- Target Recruit Count
- 161
- Registration Number
- NCT00052026
- Locations
- 🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸University of Colorado, Denver, Colorado, United States
🇺🇸Columbia University, New York, New York, United States
The Safety and Efficacy of Adjunct Carvedilol in Children With Moderate Heart Failure
- Conditions
- First Posted Date
- 2000-03-09
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Registration Number
- NCT00004854
- Locations
- 🇺🇸
Washington University School of Medicine, St. Louis, Missouri, United States
Drug Development Updates
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