Lithium cation

Generic Name: Lithium cation

Drug Type: Small Molecule

Chemical Formula: Li

CAS Number: 7439-93-2

Unique Ingredient Identifier: 8H8Z5UER66

Background: Lithium was used during the 19th century to treat gout. Lithium salts such as lithium carbonate (Li2CO3), lithium citrate, and lithium orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression. Lithium can also be used to augment other antidepressant drugs. It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. The active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several critical neuronal enzymes and neurotransmitter receptors.

Indication: Lithium, in its salt forms, is used as a mood stabilizer and for the treatment of depression and mania. It is most frequently prescribed in the treatment of bipolar disorder.

Associated Conditions: Bipolar Disorder (BD), Depression, Depression, Bipolar, Acute Manic episode

Clinical Trials

Olanzapine Versus Lithium in the Treatment of Acute Depression in Patients With Bipolar II or Bipolar Not Otherwise Specified(OL Study)

Phase 4

Completed

Conditions: Bipolar Disorder

Interventions: Drug: olanzapine
Drug: lithium

First Posted Date: 2014-11-10

Last Posted Date: 2019-12-05

Lead Sponsor: Tadashi Hasegawa

Target Recruit Count: 50

Registration Number: NCT02287259

Locations: 🇯🇵
Chiba University Hospital, Chiba-shi, Japan

Treatment of Psychosis and Agitation in Alzheimer's Disease

Phase 2

Completed

Conditions: Alzheimer's Disease
Psychosis
Agitation

Interventions: Drug: Lithium
Drug: Placebo

First Posted Date: 2014-05-02

Last Posted Date: 2024-05-02

Lead Sponsor: New York State Psychiatric Institute

Target Recruit Count: 77

Registration Number: NCT02129348

Locations: 🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States
🇺🇸
New York State Psychiatric Institute, New York, New York, United States
🇺🇸
University of Miami Miller School of Medicine, Miami, Florida, United States

and more 1 locations

Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic Episode

Phase 3

Completed

Conditions: Bipolar I Disorder

Interventions: Drug: Valproate
Drug: Lithium
Other: Placebo
Drug: Risperidone
Drug: Olanzapine

First Posted Date: 2013-11-06

Last Posted Date: 2015-11-20

Lead Sponsor: University of British Columbia

Target Recruit Count: 159

Registration Number: NCT01977300

Locations: 🇨🇦
University of British Columbia, Vancouver, British Columbia, Canada

Algorithm Guided Treatment Strategies for Bipolar Depression

Phase 4

Conditions: Bipolar Disorder

Interventions: Drug: Lithium
Drug: Shuganjieyu capsule
Drug: Quetiapine

First Posted Date: 2013-09-10

Last Posted Date: 2017-10-05

Lead Sponsor: Shanghai Mental Health Center

Target Recruit Count: 360

Registration Number: NCT01938859

Locations: 🇨🇳
Shanghai Mental Health Center, Shanghai, Shanghai, China

Lithium for Suicidal Behavior in Mood Disorders

Phase 2

Terminated

Conditions: Suicide, Attempted
Depressive Disorder
Bipolar Disorder
Suicide

Interventions: Drug: Placebo
Drug: Lithium

First Posted Date: 2013-08-26

Last Posted Date: 2024-04-29

Lead Sponsor: VA Office of Research and Development

Target Recruit Count: 519

Registration Number: NCT01928446

Locations: 🇺🇸
Michael E. DeBakey VA Medical Center, Houston, TX, Houston, Texas, United States
🇺🇸
VA Sierra Nevada Health Care System, Reno, NV, Reno, Nevada, United States
🇺🇸
Asheville VA Medical Center, Asheville, NC, Asheville, North Carolina, United States

and more 25 locations