Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Memory & Conditioning Under Anesthesia
- Conditions
- Interventions
- First Posted Date
- 2019-08-20
- Last Posted Date
- 2024-07-01
- Lead Sponsor
- Keith M. Vogt, MD, PhD
- Target Recruit Count
- 125
- Registration Number
- NCT04062123
- Locations
- 🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
The Effect of Opioid Free Anesthesia in Bariatric Surgeries
- Conditions
- Interventions
- First Posted Date
- 2019-08-07
- Last Posted Date
- 2020-06-18
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 90
- Registration Number
- NCT04048200
- Locations
- 🇪🇬
Tanta University hospitals, Tanta, Egypt
Concepts for Analgosedation During Placement of Regional Anaesthesia Before Operations.
- Conditions
- Interventions
- First Posted Date
- 2019-07-19
- Last Posted Date
- 2019-10-21
- Lead Sponsor
- Medical University of Graz
- Target Recruit Count
- 50
- Registration Number
- NCT04026074
- Locations
- 🇦🇹
Medical University Hospital LKH Graz, Graz, Austria
Development of Variable Volume Automated Mandatory Boluses for Patient-controlled Epidural Analgesia During Labour
- Conditions
- Interventions
- First Posted Date
- 2019-07-08
- Last Posted Date
- 2024-10-09
- Lead Sponsor
- KK Women's and Children's Hospital
- Target Recruit Count
- 216
- Registration Number
- NCT04011150
- Locations
- 🇸🇬
KK Women's and Children's Hospital, Singapore, Singapore
Sedation Strategies for Diagnostic Bronchoscopy 2
- Conditions
- Interventions
- First Posted Date
- 2019-06-12
- Last Posted Date
- 2019-06-14
- Lead Sponsor
- Changhai Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT03983889
- Locations
- 🇨🇳
Faculty of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China
Erector Spinae Plane Block in Scoliotic Adolescents
- First Posted Date
- 2019-05-30
- Last Posted Date
- 2019-12-03
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT03968146
- Locations
- 🇪🇬
Cairo University Hospitals, Cairo, Egypt
Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain
- Conditions
- Interventions
- First Posted Date
- 2019-05-22
- Last Posted Date
- 2020-09-11
- Lead Sponsor
- Mercy Health Ohio
- Target Recruit Count
- 6
- Registration Number
- NCT03959852
- Locations
- 🇺🇸
St. Elizabeth Boardman Hospital, Boardman, Ohio, United States
Effect of Opioids on Ventilation in Children With Obstructive Sleep Apnea
- First Posted Date
- 2019-05-06
- Last Posted Date
- 2024-07-26
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 52
- Registration Number
- NCT03938259
- Locations
- 🇺🇸
Texas childrens Hospital, Houston, Texas, United States
DOSE Trial of Opioid Sparing Effect
- Conditions
- Interventions
- First Posted Date
- 2019-05-06
- Last Posted Date
- 2021-11-05
- Lead Sponsor
- Duke University
- Target Recruit Count
- 30
- Registration Number
- NCT03938857
- Locations
- 🇺🇸
Rainbow Babies and Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States
🇺🇸MetroHealth System, Case CTSA, Cleveland, Ohio, United States
🇺🇸Arkansas Children's Hospital, Little Rock, Arkansas, United States
Comparison of Sufentanil, Fentanyl and Remifentanil in Combination With Midazolam During Bronchoscopy Under Conscious Sedation
- Conditions
- Interventions
- First Posted Date
- 2019-04-03
- Last Posted Date
- 2019-04-03
- Lead Sponsor
- Guangzhou Institute of Respiratory Disease
- Target Recruit Count
- 60
- Registration Number
- NCT03901716
- Locations
- 🇨🇳
the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Drug Development Updates
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