Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
The Use of Intranasal Fentanyl for the Treatment of Incident Dyspnea in Congestive Heart Failure: A Prospective Trial
- First Posted Date
- 2015-05-27
- Last Posted Date
- 2017-09-28
- Lead Sponsor
- St. Boniface Hospital
- Target Recruit Count
- 8
- Registration Number
- NCT02454751
- Locations
- 🇨🇦
St. Boniface General Hospital, Winnipeg, Manitoba, Canada
Comparison of Intratechal Levobupivacaine and Adding With Sufetanil and Fentanyl in Ceserean Section
- Conditions
- Interventions
- First Posted Date
- 2015-04-30
- Last Posted Date
- 2021-11-19
- Lead Sponsor
- Ankara City Hospital Bilkent
- Target Recruit Count
- 45
- Registration Number
- NCT02430090
Mechanisms of Altered Ventilatory Control in Heart Failure
- Conditions
- Interventions
- First Posted Date
- 2015-04-20
- Last Posted Date
- 2021-12-16
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 28
- Registration Number
- NCT02421341
- Locations
- 🇺🇸
Mayo Clinic - Saint Marys Hospital, Rochester, Minnesota, United States
Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia
- Conditions
- Interventions
- First Posted Date
- 2015-04-17
- Last Posted Date
- 2019-10-09
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 11
- Registration Number
- NCT02419547
- Locations
- 🇺🇸
Brigahm and Women's Hospital, Boston, Massachusetts, United States
Comparison Between Conventional and Model-based Infusion Strategy of IV PCA in Patients Undergoing RALP
- First Posted Date
- 2015-03-30
- Last Posted Date
- 2015-12-02
- Lead Sponsor
- Asan Medical Center
- Target Recruit Count
- 111
- Registration Number
- NCT02402621
- Locations
- 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of
Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants
- First Posted Date
- 2015-03-23
- Last Posted Date
- 2017-10-26
- Lead Sponsor
- The Medicines Company
- Target Recruit Count
- 71
- Registration Number
- NCT02395653
- Locations
- 🇺🇸
Packard Children's Hospital at Stanford, Palo Alto, California, United States
🇺🇸The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
🇺🇸Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, United States
Pediatric Ketamine Study for Pain Management
- First Posted Date
- 2015-03-17
- Last Posted Date
- 2018-05-08
- Lead Sponsor
- Antonios Likourezos
- Target Recruit Count
- 22
- Registration Number
- NCT02388321
- Locations
- 🇺🇸
Maimonides Medical Center, Brooklyn, New York, United States
Use of Intrathecal Fentanyl and Development of Hyperalgesia in Patients Undergoing Elective Cesarean
- First Posted Date
- 2015-03-12
- Last Posted Date
- 2015-03-12
- Lead Sponsor
- Pontificia Universidad Catolica de Chile
- Target Recruit Count
- 80
- Registration Number
- NCT02387060
- Locations
- 🇨🇱
Hospital Clinico Pontificia Universidad Catolica, Santiago, Región Metropolitana, Chile
A Comparative Study of the Effect of Epidural Dexmedetomidine Versus Fentanyl Added to Ropivacaine in Pediatric Orthopedic Surgery
- Conditions
- Interventions
- First Posted Date
- 2015-03-02
- Last Posted Date
- 2016-08-17
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 58
- Registration Number
- NCT02375191
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of
Remifentanil and Glycemic Response in Cardiac Surgery
- First Posted Date
- 2015-01-28
- Last Posted Date
- 2020-04-21
- Lead Sponsor
- Kathirvel Subramaniam
- Target Recruit Count
- 116
- Registration Number
- NCT02349152
- Locations
- 🇺🇸
UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania, United States
Drug Development Updates
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