Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Analgesic Effect of Perineural Fentanyl Additive to Local Anesthetics in Femoral Nerve Block
- First Posted Date
- 2015-01-06
- Last Posted Date
- 2016-07-27
- Lead Sponsor
- Chonnam National University Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT02331576
- Locations
- 🇰🇷
Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, Korea, Republic of
Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy
- First Posted Date
- 2014-12-31
- Last Posted Date
- 2018-11-30
- Lead Sponsor
- B.P. Koirala Institute of Health Sciences
- Target Recruit Count
- 90
- Registration Number
- NCT02327923
- Locations
- 🇳🇵
BP Koirala Institute of Health Sciences, Dharan, Sunsari District, Nepal
Influence of Epidural Analgesia on Natural Killer Cell (NK) Activity After Colonic Cancer Surgery
- Conditions
- Interventions
- First Posted Date
- 2014-12-29
- Last Posted Date
- 2014-12-29
- Lead Sponsor
- Hillel Yaffe Medical Center
- Target Recruit Count
- 30
- Registration Number
- NCT02326727
- Locations
- 🇮🇱
Hillel Yaffe Medical Center, Hadera, Israel
Post-Operative Pain Control in Opioid Tolerant Patients: Fentanyl Challenge Protocol Versus Standard of Care
- First Posted Date
- 2014-12-24
- Last Posted Date
- 2015-11-01
- Lead Sponsor
- Bassett Healthcare
- Registration Number
- NCT02324933
- Locations
- 🇺🇸
Bassett Healthcare Network, Cooperstown, New York, United States
Intravenous Metoclopramide in the Acute Treatment of Migraine: A Double-blind, Randomized, Placebo-controlled Trial
- Conditions
- Interventions
- First Posted Date
- 2014-12-11
- Last Posted Date
- 2017-01-04
- Lead Sponsor
- Kocaeli University
- Target Recruit Count
- 148
- Registration Number
- NCT02314351
- Locations
- 🇹🇷
Kocaeli University, Faculty of Medicine, Kocaeli, Turkey
The Efficacy and the Safety of Dexmedetomidine Sedation on the Pediatric Intensive Unit(PICU) Patients.
- Conditions
- Interventions
- First Posted Date
- 2014-11-20
- Last Posted Date
- 2014-11-21
- Lead Sponsor
- Anhui Provincial Children's Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT02296073
Comparison of Regimens MPIB, CIPCEA, PCEA
- Conditions
- Interventions
- First Posted Date
- 2014-10-30
- Last Posted Date
- 2024-10-09
- Lead Sponsor
- KK Women's and Children's Hospital
- Target Recruit Count
- 839
- Registration Number
- NCT02278601
- Locations
- 🇸🇬
KK Women's and Children's Hospital, Singapore, Singapore
Intrathecal Hydromorphone for Labor Analgesia
- Conditions
- Interventions
- First Posted Date
- 2014-10-29
- Last Posted Date
- 2022-03-18
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 21
- Registration Number
- NCT02277782
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Opioid Effects on Cognitive Function Following Colonoscopy
- Conditions
- Interventions
- First Posted Date
- 2014-10-17
- Last Posted Date
- 2016-06-29
- Lead Sponsor
- Perihan Ekmekçi
- Target Recruit Count
- 150
- Registration Number
- NCT02267681
- Locations
- 🇹🇷
Ufuk University Dr Rıdvan Ege Hospital, Ankara, Turkey
Can Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?
- First Posted Date
- 2014-09-30
- Last Posted Date
- 2015-01-09
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Target Recruit Count
- 21
- Registration Number
- NCT02252458
- Locations
- 🇨🇭
Department of Anesthesia, University of Basel Hospital, Basel, Switzerland
Drug Development Updates
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