Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Perioperative Pain Management for Lumbar Spine Surgery
- Conditions
- Pain, Postoperative
- Interventions
- First Posted Date
- 2024-10-28
- Last Posted Date
- 2024-10-28
- Lead Sponsor
- Benha University
- Target Recruit Count
- 75
- Registration Number
- NCT06662318
- Locations
- 🇪🇬
Benha University, Banhā, El Qalyoubia, Egypt
Opioid Free Anesthesia Versus Opioid Based Anesthesia
- Conditions
- Opioid Free AnesthesiaLaparoscopic Bariatric Surgeries
- Interventions
- Drug: Dexamedomedine and ketamine infusion
- First Posted Date
- 2024-10-21
- Last Posted Date
- 2024-10-21
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 36
- Registration Number
- NCT06650371
Dexmedetomidine Ropivacaine Versus Plain Ropivacaine in Bilateral Pectoralis Nerve (PECS) Block
- Conditions
- Analgesia
- Interventions
- First Posted Date
- 2024-10-10
- Last Posted Date
- 2024-10-11
- Lead Sponsor
- Fayoum University
- Target Recruit Count
- 90
- Registration Number
- NCT06636578
- Locations
- 🇪🇬
Mohamed Hamed, Fayoum, Egypt
🇪🇬Fayoum University Hospital, Fayoum, Egypt
Comparing Ketamine and Fentanyl in Pediatric Tonsillectomy: Pain Control and Emergence Delirium Outcomes (KVFPT)
- Conditions
- Postoperative Pain, AcuteEmergence Delirium
- Interventions
- First Posted Date
- 2024-10-08
- Last Posted Date
- 2024-10-30
- Lead Sponsor
- Medipol University
- Target Recruit Count
- 59
- Registration Number
- NCT06630364
- Locations
- 🇹🇷
Medipol Mega University Hospital, Istanbul, Bagcılar, Turkey
Intranasal Fentanyl in Preterm Infants Undergoing Peripherally Inserted Central Catheter Placement
- First Posted Date
- 2024-09-19
- Last Posted Date
- 2025-02-20
- Lead Sponsor
- Mount Sinai Hospital, Canada
- Target Recruit Count
- 8
- Registration Number
- NCT06590870
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Paracetamol Plus Tramadol Versus Fentanyl As Preemptive Analgesia For Enhanced Recovery After Day Case Surgeries
- Conditions
- Preemptive Paracetamol Plus Tramadol and Preemptive Fentanyl
- Interventions
- First Posted Date
- 2024-08-20
- Last Posted Date
- 2024-08-20
- Lead Sponsor
- Zagazig University
- Target Recruit Count
- 102
- Registration Number
- NCT06561672
- Locations
- 🇪🇬
Aculty of Medicine,Zagazig University, Zagazig, El Sharkia, Egypt
Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol, Meperidine, and Paracetamol in Renal Colic
- Conditions
- AnalgesiaRenal Colic
- Interventions
- First Posted Date
- 2024-08-19
- Last Posted Date
- 2024-08-19
- Lead Sponsor
- Ismail Tekin
- Target Recruit Count
- 90
- Registration Number
- NCT06558916
Lidocaine Versus Fentanyl for Hemodynamic Stability
- Conditions
- HypertensionFentanylLidocaine
- Interventions
- First Posted Date
- 2024-08-16
- Last Posted Date
- 2024-08-23
- Lead Sponsor
- Theodor Bilharz Research Institute
- Target Recruit Count
- 40
- Registration Number
- NCT06557473
- Locations
- 🇪🇬
Theodor Bilharz Research Institute, Giza, Egypt
Efficacy of Remifentanil in Preventing Emergence Agitation
- Conditions
- Emergence Agitation
- Interventions
- First Posted Date
- 2024-08-06
- Last Posted Date
- 2024-08-06
- Lead Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
- Target Recruit Count
- 99
- Registration Number
- NCT06539013
- Locations
- 🇹🇷
Health Sciences University Gazi Yaşargil Training and Research Hospital, Diyarbakır, Kayapınar, Turkey
Efficacy of Fentanyl Soaked Nasal Packs on Postoperative Pain in Nasal Surgeries.
- First Posted Date
- 2024-08-01
- Last Posted Date
- 2024-08-01
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 100
- Registration Number
- NCT06531759
Drug Development Updates
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