Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at the Moment of Starting 3rd Step of WHO Analgesic Ladder.
- Conditions
- Cancer PainCancer
- Interventions
- First Posted Date
- 2013-03-12
- Last Posted Date
- 2015-12-24
- Lead Sponsor
- Mario Negri Institute for Pharmacological Research
- Target Recruit Count
- 518
- Registration Number
- NCT01809106
- Locations
- 🇮🇹
Multimedica, Sesto San Giovanni, Italy
🇮🇹Istituto Scientifico San Raffaele, Milano, Italy
🇮🇹Arcispedale S. Maria Nuova Azienda Ospedaliera, Reggio Emilia, RE, Italy
An Efficacy and Safety Study of Fentanyl Transdermal Patch in Filipino Participants With Osteoarthritis and Chronic Low Back Pain
- First Posted Date
- 2013-02-21
- Last Posted Date
- 2013-07-15
- Lead Sponsor
- Janssen Pharmaceutica
- Target Recruit Count
- 237
- Registration Number
- NCT01795898
Intrathecal Magnesium for Same-day-surgery
- Conditions
- Transient Neurologic Syndrome
- Interventions
- First Posted Date
- 2013-02-18
- Last Posted Date
- 2014-03-10
- Lead Sponsor
- Hospital General de Ciudad Real
- Target Recruit Count
- 21
- Registration Number
- NCT01794247
- Locations
- 🇪🇸
Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
🇪🇸Hospital General universitario de Ciudad Real, Ciudad Real, Castilla-La Mancha, Spain
Comparison of Intubation With Nerve Block and With Sedation in Awake Patients
- Conditions
- Intubation Complication
- Interventions
- First Posted Date
- 2013-01-15
- Last Posted Date
- 2013-01-15
- Lead Sponsor
- Tehran University of Medical Sciences
- Target Recruit Count
- 70
- Registration Number
- NCT01768377
- Locations
- 🇮🇷
Imam Khomeini Hospital, Tehran, Iran, Islamic Republic of
Pharmacokinetic Characterization of the Active, Separated System With PK Controller (Fentanyl Iontophoretic Transdermal System, 40 Mcg Fentanyl Per Activation).
- First Posted Date
- 2012-12-17
- Last Posted Date
- 2013-04-19
- Lead Sponsor
- Incline Therapeutics, Inc.
- Target Recruit Count
- 54
- Registration Number
- NCT01750060
- Locations
- 🇺🇸
PRACS Institute, Ltd., Fargo, North Dakota, United States
Comparison of Propofol-fentanyl and Midazolam-fentanyl for Conscious Sedation
- First Posted Date
- 2012-12-13
- Last Posted Date
- 2012-12-13
- Lead Sponsor
- Tehran University of Medical Sciences
- Target Recruit Count
- 60
- Registration Number
- NCT01749579
- Locations
- 🇮🇷
Imam Khomeini Hospital, Tehran, Iran, Islamic Republic of
Effects of Dexmedetomidine on the Postoperative Experience in Children
- Conditions
- Failed Moderate Sedation During Procedure
- Interventions
- First Posted Date
- 2012-12-12
- Last Posted Date
- 2012-12-12
- Lead Sponsor
- Inonu University
- Target Recruit Count
- 42
- Registration Number
- NCT01748630
- Locations
- 🇹🇷
Inonu University Turgut Ozal Medical Center, Malatya, Turkey
Etomidate Emulsion for Sedation in Patients Scheduled for Upper Gastrointestinal (GI) Endoscopy
- Conditions
- Complication of Gastrostomy
- Interventions
- First Posted Date
- 2012-11-20
- Last Posted Date
- 2013-05-13
- Lead Sponsor
- Jiangsu Nhwa Pharmaceutical Co., Ltd.
- Target Recruit Count
- 328
- Registration Number
- NCT01729897
Ketamine in Bariatric Surgery
- First Posted Date
- 2012-11-12
- Last Posted Date
- 2012-11-12
- Lead Sponsor
- University of Padova
- Target Recruit Count
- 90
- Registration Number
- NCT01724983
- Locations
- 🇮🇹
Azienda Ospedaliera, Padova, PD, Italy
Intranasal Fentanyl as an Analgesic for Cystoscopic Procedures
- First Posted Date
- 2012-10-16
- Last Posted Date
- 2015-08-20
- Target Recruit Count
- 71
- Registration Number
- NCT01708122
- Locations
- 🇺🇸
Harbor UCLA Medical Center Urology Clinic, Torrance, California, United States
Drug Development Updates
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