Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Investigation of Analgesic and Anti-hyperalgesic Effect of Opioids in Experimental Pain
- First Posted Date
- 2008-03-31
- Last Posted Date
- 2012-09-14
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 22
- Registration Number
- NCT00647127
- Locations
- 🇩🇰
Mech Sense, Department of Gastroenterology, Aalborg, Region Nordjyllan, Denmark
An Efficacy and Safety Study of Fentanyl (JNS020QD) in Participants With Cancer Pain
- First Posted Date
- 2008-03-24
- Last Posted Date
- 2013-06-07
- Lead Sponsor
- Janssen Pharmaceutical K.K.
- Target Recruit Count
- 66
- Registration Number
- NCT00641667
Analgesic Effect and Plasma Concentration of Epidural Versus Intravenous Fentanyl
- First Posted Date
- 2008-03-14
- Last Posted Date
- 2008-03-14
- Lead Sponsor
- Federal University of São Paulo
- Target Recruit Count
- 30
- Registration Number
- NCT00635986
Continuous Infusion of Fentanyl in Preterm on MV
- Conditions
- PainInfant, Premature, DiseasesRespiration; Insufficient or Poor, Newborn
- Interventions
- Drug: 5% glucose solutionDrug: Fentanyl
- First Posted Date
- 2007-12-12
- Last Posted Date
- 2011-10-12
- Target Recruit Count
- 128
- Registration Number
- NCT00571636
- Locations
- 🇮🇹
St'Orsola-Malpighi General Hospital, Bologna, BO, Italy
Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty
- Conditions
- Osteoarthritis of the Knee
- Interventions
- First Posted Date
- 2007-11-22
- Last Posted Date
- 2011-08-08
- Lead Sponsor
- Asker & Baerum Hospital
- Target Recruit Count
- 102
- Registration Number
- NCT00562627
- Locations
- 🇳🇴
Asker and Baerum Hospital, Rud, Norway
Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery
- Conditions
- Breast Cancer
- Interventions
- First Posted Date
- 2007-10-11
- Last Posted Date
- 2015-04-13
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 89
- Registration Number
- NCT00542542
- Locations
- 🇺🇸
UT MD Anderson Cancer Center, Houston, Texas, United States
Effects of General Anesthesia and Spinal-Morphine Anesthesia on Recovery and Comfort After Benign Abdominal Hysterectomy
- Conditions
- Hysterectomy (MeSH nr: E04.950.300.399)
- Interventions
- First Posted Date
- 2007-09-10
- Last Posted Date
- 2012-01-26
- Lead Sponsor
- Preben Kjolhede
- Target Recruit Count
- 180
- Registration Number
- NCT00527332
- Locations
- 🇸🇪
Värnamo Hospital, Värnamo, Sweden
🇸🇪Eksjö Hospital, Eksjö, Sweden
🇸🇪Ryhov Hospital, Jönköping, Sweden
Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy
- First Posted Date
- 2007-05-01
- Last Posted Date
- 2016-12-05
- Target Recruit Count
- 122
- Registration Number
- NCT00468052
- Locations
- 🇺🇸
UMDNJ University Hospital, Newark, New Jersey, United States
Neuronal Mechanisms of Sensory Processing During General Anesthesia
- Conditions
- General Anesthesia
- First Posted Date
- 2007-02-13
- Last Posted Date
- 2010-07-30
- Lead Sponsor
- Ludwig-Maximilians - University of Munich
- Target Recruit Count
- 768
- Registration Number
- NCT00434382
- Locations
- 🇩🇪
Klinik fuer Anaesthesiologie am Universitätsklinikum Schleswig Holstein, Campus Luebeck, Lubeck, Germany
🇩🇪Klinik fuer Anaesthesiologie der Ludwigs-Maximilians-Universitaet Muenchen, Munich, Germany
🇩🇪Krankenhaus Friedrichshafen, Friedrichshafen, Germany
Rapip Study: Clinical Trial on Remifentanyl for Analgesia and Sedation of Ventilated Neonates and Infants
- First Posted Date
- 2007-01-08
- Last Posted Date
- 2010-06-25
- Lead Sponsor
- University of Cologne
- Target Recruit Count
- 24
- Registration Number
- NCT00419601
- Locations
- 🇩🇪
Clinic for Paediatrics, University of Cologne Kerpener Str. 62, Cologne, Germany
Drug Development Updates
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