Norepinephrine
- Generic Name
- Norepinephrine
- Brand Names
- Levophed
- Drug Type
- Small Molecule
- Chemical Formula
- C8H11NO3
- CAS Number
- 51-41-2
- Unique Ingredient Identifier
- X4W3ENH1CV
- Background
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
- Indication
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
- Associated Conditions
- Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
- Associated Therapies
- -
Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock
- First Posted Date
- 2015-06-16
- Last Posted Date
- 2023-03-07
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 398
- Registration Number
- NCT02473263
- Locations
- 🇫🇷
Anesthesiology, Intensive Care Unit and emergency department - Necker Hospital, Paris, France
To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock
- Conditions
- Interventions
- First Posted Date
- 2015-06-10
- Last Posted Date
- 2017-11-06
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 184
- Registration Number
- NCT02468063
- Locations
- 🇮🇳
Institute of Liver and Biliary Sciences, New Delhi, Delhi, India
NOrepinephrine and VasoprEssin Versus Norepinephrine aLone in Critically Ill Patients With Septic Shock
- First Posted Date
- 2015-05-27
- Last Posted Date
- 2017-11-29
- Lead Sponsor
- University of Arkansas
- Registration Number
- NCT02454348
- Locations
- 🇺🇸
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Renal Perfusion, Filtration and Oxygenation After Liver Transplantation -Effects of av Postoperative Blood Pressure
- Conditions
- Interventions
- First Posted Date
- 2015-05-27
- Last Posted Date
- 2016-09-28
- Lead Sponsor
- Sahlgrenska University Hospital, Sweden
- Target Recruit Count
- 12
- Registration Number
- NCT02455115
- Locations
- 🇸🇪
Sahlgrenska University Hospital, dpt of anesthesiology and intensive care, Göteborg, VGR, Sweden
Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly
- First Posted Date
- 2015-04-28
- Last Posted Date
- 2018-04-13
- Target Recruit Count
- 1812
- Registration Number
- NCT02428062
- Locations
- 🇮🇹
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico; Via F. Sforza 35, Milano, Italy
Pressure-dependent Changes in Hematocrit and Plasma Volume During Anesthesia
- Conditions
- Interventions
- First Posted Date
- 2015-04-09
- Last Posted Date
- 2015-04-09
- Lead Sponsor
- Sahlgrenska University Hospital, Sweden
- Target Recruit Count
- 24
- Registration Number
- NCT02412189
- Locations
- 🇸🇪
Sahlgrenska University Hospital, Gothenburg, Sweden
Phenylephrine vs. Norepinephrine Infusion After Spinal Anesthesia for Cesarean Delivery
- Conditions
- Interventions
- First Posted Date
- 2015-02-03
- Last Posted Date
- 2017-01-04
- Lead Sponsor
- West Virginia University
- Target Recruit Count
- 85
- Registration Number
- NCT02354833
- Locations
- 🇺🇸
West Virginia University Hospital, Morgantown, West Virginia, United States
The Effect of Terlipressin on Intesitnal Function in Septic Shock Patients
- First Posted Date
- 2014-12-03
- Last Posted Date
- 2014-12-30
- Lead Sponsor
- Liu ZiMeng
- Target Recruit Count
- 40
- Registration Number
- NCT02306239
- Locations
- 🇨🇳
the First Affiliated Hospital of Sumyetsan University, Guangzhou, Guangdong, China
The Effect of Norepinephrine and Dopamine on Radial Forearm Free Flap Tissue Oxygen Pressure and Microdialysate Metabolite Measurements
- Conditions
- Interventions
- First Posted Date
- 2014-09-16
- Last Posted Date
- 2014-09-16
- Lead Sponsor
- Tampere University Hospital
- Target Recruit Count
- 25
- Registration Number
- NCT02241083
- Locations
- 🇫🇮
Tampere University Hospital, Tampere, P.O. Box 2000, Finland
Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients
- Conditions
- Interventions
- First Posted Date
- 2014-07-30
- Last Posted Date
- 2018-06-13
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 17
- Registration Number
- NCT02203630
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Drug Development Updates
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