Norepinephrine
- Generic Name
- Norepinephrine
- Brand Names
- Levophed
- Drug Type
- Small Molecule
- Chemical Formula
- C8H11NO3
- CAS Number
- 51-41-2
- Unique Ingredient Identifier
- X4W3ENH1CV
- Background
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
- Indication
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
- Associated Conditions
- Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
The Effect of Vasopressor on Pressure Injury Development
- Conditions
- Pressure UlcerVasopressor Adverse ReactionPressure Injury
- Interventions
- First Posted Date
- 2023-12-08
- Last Posted Date
- 2023-12-21
- Lead Sponsor
- Koç University
- Target Recruit Count
- 148
- Registration Number
- NCT06163352
- Locations
- 🇹🇷
Koç University, Istanbul, None Selected, Turkey
ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment
- Conditions
- Adverse Effect
- Interventions
- First Posted Date
- 2023-12-06
- Last Posted Date
- 2023-12-06
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Target Recruit Count
- 80
- Registration Number
- NCT06158009
ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment in Preeclamptic Patients
- Conditions
- Adverse Effect
- Interventions
- First Posted Date
- 2023-12-06
- Last Posted Date
- 2023-12-06
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Target Recruit Count
- 80
- Registration Number
- NCT06158035
ED90 of Norepinephrine and Phenylephrine Infusions Under Intensive Treatment in Preeclamptic Patients
- Conditions
- Adverse Effect
- Interventions
- First Posted Date
- 2023-12-06
- Last Posted Date
- 2024-12-04
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Target Recruit Count
- 80
- Registration Number
- NCT06158022
- Locations
- 🇨🇳
General hospital of Ningxia University, Yinchuan, Ningxia, China
ED90 of Norepinephrine and Phenylephrine Infusions Under Intensive Treatment
- Conditions
- Adverse Effect
- Interventions
- First Posted Date
- 2023-12-06
- Last Posted Date
- 2023-12-06
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Target Recruit Count
- 80
- Registration Number
- NCT06158048
Clinical Research on Shenfu Injection in Septic Patients
- Conditions
- Sepsis
- Interventions
- First Posted Date
- 2023-12-05
- Last Posted Date
- 2023-12-05
- Lead Sponsor
- Ruijin Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT06157320
- Locations
- 🇨🇳
Ruijin Hospital, Shanghai, Shanghai, China
Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit
- Conditions
- Hypotension and ShockSeptic ShockNorepinephrine Adverse Reaction
- First Posted Date
- 2023-11-07
- Last Posted Date
- 2024-03-12
- Lead Sponsor
- Region Skane
- Target Recruit Count
- 473
- Registration Number
- NCT06121115
- Locations
- 🇸🇪
Skåne University Hospital, Malmö, Sweden
The Effect of Two Different Doses of Noradrenaline on Hypotension Caused by Spinal Anesthesia for Cesarean Section
- Conditions
- HypotensionCesarean SectionNorepinephrine
- Interventions
- First Posted Date
- 2023-10-26
- Last Posted Date
- 2023-10-30
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 100
- Registration Number
- NCT06102382
Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia
- First Posted Date
- 2023-10-16
- Last Posted Date
- 2024-12-17
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 32
- Registration Number
- NCT06083948
- Locations
- 🇩🇰
Aarhus University Hospital, Aarhus, Denmark
Induced Hypertension in Acute PRogrESsive Perforating Artery Stroke Using Peripheral Dilute noREpinephrine
- Conditions
- Stroke, AcuteStroke, Ischemic
- Interventions
- First Posted Date
- 2023-09-28
- Last Posted Date
- 2025-01-09
- Lead Sponsor
- University Hospital, Bordeaux
- Target Recruit Count
- 358
- Registration Number
- NCT06059144
- Locations
- 🇫🇷
CHU de Bordeaux, Bordeaux, France
Drug Development Updates
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