Norepinephrine

Generic Name: Norepinephrine

Brand Names: Levophed

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₁NO_₃

CAS Number: 51-41-2

Unique Ingredient Identifier: X4W3ENH1CV

Background: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Indication: Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Associated Conditions: Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension

Associated Therapies: -

Clinical Trials

HIgh Versus STAndard Blood Pressure Target in Hypertensive High-risk Patients Undergoing Major Abdominal Surgery

Not Applicable

Recruiting

Conditions: Complication,Postoperative
Intraoperative Hypotension
Blood Pressure

Interventions: Drug: Ephedrine
Drug: Norepinephrine
Drug: Etilefrine Hydrochloride bolus
Diagnostic Test: Use of pulse pressure and stroke volume variation (PPV and SVV); use of Mini Fluid Challenge (mini_FC)

First Posted Date: 2022-12-05

Last Posted Date: 2024-11-01

Lead Sponsor: Humanitas Clinical and Research Center

Target Recruit Count: 636

Registration Number: NCT05637606

Locations: 🇮🇹
Azienda Ospedaliero - Universitaria SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
🇮🇹
Istituto Europeo di Oncologia (IEO), Milano, Italy
🇮🇹
Department of Anesthesia, Critical Care and Pain Medicine, SS. Annunziata Hospital, Chieti, Abruzzo, Italy

and more 15 locations

Evaluation of the Superiority of VAsopressin Versus NOradrenaline in the Management of Patients at Risk of Kidney Failure Undergoing Cardiac Surgery With Extracorporeal Circulation

Phase 3

Recruiting

Conditions: Vasoplegic Syndrome
Scheduled Cardiac Surgery With Extracorporeal Circulation

Interventions: Drug: Vasopressin
Drug: Norepinephrine
Other: Collection of clinical data
Other: Quality of Life Questionnaire EQ-5D

First Posted Date: 2022-10-05

Last Posted Date: 2023-09-08

Lead Sponsor: Centre Hospitalier Universitaire Dijon

Target Recruit Count: 840

Registration Number: NCT05568160

Locations: 🇫🇷
Chu Dijon Bourgogne, Dijon, France

Sex Differences in Sympathetic Vascular Reactivity at High Altitude

Not Applicable

Completed

Conditions: Vasodilation
Vasoconstriction

Interventions: Drug: Sodium Nitroprusside
Drug: Phenylephrine Hydrochloride
Drug: Norepinephrine
Other: Isometric Handgrip and Post-Exercise Circulatory Occlusion
Other: Rhythmic Handgrip
Other: Cold Pressor Test
Drug: Propranolol Hydrochloride
Drug: Phentolamine Mesylate

First Posted Date: 2022-09-01

Last Posted Date: 2023-03-23

Lead Sponsor: University of Alberta

Target Recruit Count: 17

Registration Number: NCT05525416

Locations: 🇨🇦
University of Alberta, Edmonton, Alberta, Canada
🇨🇦
University of British Columbia - Okanagan, Kelowna, British Columbia, Canada

Comparative Efficacity of Ephedrine Versus Norepinephrine to Correct Anesthesia Induction Related Hypotension

Phase 3

Recruiting

Conditions: Hypotension on Induction

Interventions: Drug: Ephedrine
Drug: Norepinephrine

First Posted Date: 2022-08-11

Last Posted Date: 2022-09-16

Lead Sponsor: Brugmann University Hospital

Target Recruit Count: 60

Registration Number: NCT05497700

Locations: 🇧🇪
CHU Brugmann, Brussels, Belgium

The Effect of Epinephrine, Norepinephrine and Phenylephrine on Intraoperative Hemodynamic Performance

Phase 4

Recruiting

Conditions: Cardiac Output, Low
Cardiac Output, High
Perfusion; Complications

Interventions: Drug: Epinephrin
Drug: Norepinephrine
Drug: Phenylephrine

First Posted Date: 2022-08-09

Last Posted Date: 2022-10-19

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 225

Registration Number: NCT05492968

Locations: 🇦🇹
Medical University of Vienna, Vienna, Austria

Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (MRI Part)

Not Applicable

Not yet recruiting

Conditions: Carotid Endarterectomy

Interventions: Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2022-06-10

Last Posted Date: 2023-08-24

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 60

Registration Number: NCT05414877

Comparison Between Three Norepinephrine Bolus Doses for Management of Post-spinal Hypotension During Ceaserian Section for Patients With Preeclampsia

Phase 4

Completed

Conditions: Anesthesia; Adverse Effect
Cesarean Section Complications

Interventions: Drug: Norepinephrine

First Posted Date: 2022-05-10

Last Posted Date: 2022-08-18

Lead Sponsor: Kasr El Aini Hospital

Target Recruit Count: 60

Registration Number: NCT05368415

Locations: 🇪🇬
Cairo university, Kasr Alainy hospital, Cairo, Egypt

Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure

Phase 3

Completed

Conditions: Hypotension and Shock
Anesthesia Intubation Complication
Respiratory Failure
Intubation Complication
Hypotension on Induction

Interventions: Drug: Norepinephrine
Drug: Lactated Ringers, Intravenous
Drug: normal saline
Drug: Plasma-lyte

First Posted Date: 2022-05-02

Last Posted Date: 2024-07-15

Lead Sponsor: Wright State University

Target Recruit Count: 42

Registration Number: NCT05355974

Locations: 🇺🇸
Miami Valley Hospital Premier Health, Dayton, Ohio, United States

Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis

Recruiting

Conditions: Late-Onset Neonatal Sepsis
Neonatal Hypotension
Extreme Prematurity

Interventions: Drug: Dopamine
Drug: Norepinephrine

First Posted Date: 2022-04-26

Last Posted Date: 2024-11-08

Lead Sponsor: Mount Sinai Hospital, Canada

Target Recruit Count: 550

Registration Number: NCT05347238

Locations: 🇺🇸
Banner-University Medical Center Phoenix, Phoenix, Arizona, United States
🇺🇸
Dayton Children's Hospital, Dayton, Ohio, United States
🇺🇸
El Paso Children's Hospital, El Paso, Texas, United States

and more 23 locations

Therapeutic Study Evaluating the Efficacy of Noradrenaline in the Prevention of Hypotension Related to Intubation for Cardiac or Thoracic Surgery

Phase 3

Completed

Conditions: Cardiac Disorder
Hypotension

Interventions: Drug: noradrenaline

First Posted Date: 2022-04-20

Last Posted Date: 2024-03-07

Lead Sponsor: Nantes University Hospital

Target Recruit Count: 211

Registration Number: NCT05335954

Locations: 🇫🇷
Chu de Nantes, Nantes, France

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